人类支气管和细支气管中的纤毛摆动频率。
Ciliary beat frequency in human bronchi and bronchioles.
作者信息
Clary-Meinesz C, Mouroux J, Huitorel P, Cosson J, Schoevaert D, Blaive B
机构信息
Service de Pneumologie, Hôpital Pasteur, Nice, France.
出版信息
Chest. 1997 Mar;111(3):692-7. doi: 10.1378/chest.111.3.692.
STUDY OBJECTIVE
This study aimed to determine the differences between ciliary beat frequencies of respiratory ciliated cells from peripheral bronchioles and from proximal bronchi in humans.
DESIGN
Measurements were made from resected lungs. Ciliated cells were harvested by brushing the mucosa of each site immediately after surgery. Brushings with a cytology brush were performed on normal areas of the resected cartilaginous bronchus for proximal samplings and through a peripheral bronchiole close to the visceral pleura for peripheral samplings. For each site, at least 12 different measurements were made at 22 degrees C using an image analysis system.
RESULTS
A highly significant difference between proximal bronchi (mean, 7.1 Hz; SD, 1.29) and peripheral bronchioles (mean, 4.6 Hz; SD, 1.39) (p < 0.0001) was found.
CONCLUSION
Thus, cilia from peripheral bronchioles beat at a 35% lower beat frequency than cilia from proximal bronchi.
研究目的
本研究旨在确定人类外周细支气管和近端支气管呼吸纤毛细胞的纤毛摆动频率之间的差异。
设计
从切除的肺组织进行测量。术后立即通过刷取每个部位的黏膜来获取纤毛细胞。使用细胞学刷在切除的软骨性支气管的正常区域进行刷取以获取近端样本，并通过靠近脏层胸膜的外周细支气管进行刷取以获取外周样本。对于每个部位，在22摄氏度下使用图像分析系统进行至少12次不同的测量。
结果
发现近端支气管（平均值为7.1赫兹；标准差为1.29）和外周细支气管（平均值为4.6赫兹；标准差为1.39）之间存在高度显著差异（p < 0.0001）。
结论
因此，外周细支气管的纤毛摆动频率比近端支气管的纤毛低35%。
Zotero 插件