移植肺中的纤毛摆动频率。
Ciliary beat frequency in transplanted lungs.
作者信息
Veale D, Glasper P N, Gascoigne A, Dark J H, Gibson G J, Corris P A
机构信息
Department of Respiratory Medicine, Freeman Hospital, Newcastle upon Tyne.
出版信息
Thorax. 1993 Jun;48(6):629-31. doi: 10.1136/thx.48.6.629.
BACKGROUND
Patients with lung transplantation are prone to respiratory infections. Generally this is attributable to the effects of immunosuppressive drugs but mucociliary clearance has been found to be impaired in these subjects. A study was performed to determine whether this finding is accompanied by a reduction in ciliary beat frequency (CBF).
METHODS
Six patients who had undergone single lung transplantation for fibrosing lung disease were investigated. CBF was measured in mucosal samples from native and transplanted bronchi by a videophotometry method.
RESULTS
The CBF was reduced in the transplanted bronchi in all cases when both fastest and slowest beating cilia were examined. The fastest beating cilia on the native side had a mean (SD) CBF of 12.1 (1.3) Hz compared with 9.6 (2.0) Hz on the transplanted side. The slowest beating cilia also had reduced CBF on the transplanted side.
CONCLUSION
In patients with fibrotic lung disease, CBF is reduced in transplanted bronchi in comparison with native bronchi.
背景
肺移植患者易发生呼吸道感染。一般来说，这归因于免疫抑制药物的作用，但已发现这些患者的黏液纤毛清除功能受损。进行了一项研究以确定这一发现是否伴随着纤毛摆动频率（CBF）的降低。
方法
对6例因纤维化肺病接受单肺移植的患者进行了研究。通过视频光度法测量来自天然支气管和移植支气管的黏膜样本中的CBF。
结果
在检查最快和最慢摆动的纤毛时，所有病例中移植支气管的CBF均降低。天然侧最快摆动的纤毛平均（标准差）CBF为12.1（1.3）Hz，而移植侧为9.6（2.0）Hz。移植侧最慢摆动的纤毛的CBF也降低。
结论
在纤维化肺病患者中，与天然支气管相比，移植支气管的CBF降低。
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