在日本人中发现的一种新的HLA - B抗原（HOK - 1）。

A new HLA-B antigen (HOK-1) found in the Japanese.

作者信息

Nakai Y, Kano T, Asanuma T, Moriuchi J, Wakisaka A, Aizawa M, Itakura K

出版信息

Tissue Antigens. 1979 Jul;14(1):47-51. doi: 10.1111/j.1399-0039.1979.tb00820.x.

DOI:10.1111/j.1399-0039.1979.tb00820.x

Abstract

The HLA-B8 antigen is one of the characteristic antigens associated with organ specific autoimmune diseases among Caucasians. Among the Japanese, HLA-B8 positives have been assumed to be extremely rare. By using some HLA-B8 typing sera, a new HLA-B antigen, HLA-Bw4 positive, was found in the Japanese. This new HLA-B antigen, tentatively called HOK-1, showed a phenotype frequency of 3.7% and a gene frequency of 1.9 +/- 0.6%. This antigen has a strong linkage disequilibrium with HLA-Cw1 among the Japanese.

摘要

HLA - B8抗原是高加索人中与器官特异性自身免疫性疾病相关的特征性抗原之一。在日本人中，HLA - B8阳性者被认为极为罕见。通过使用一些HLA - B8分型血清，在日本人中发现了一种新的HLA - B抗原，即HLA - Bw4阳性。这种新的HLA - B抗原，暂称为HOK - 1，其表型频率为3.7%，基因频率为1.9±0.6%。在日本人中，该抗原与HLA - Cw1存在强连锁不平衡。