Ohashi Y
Department of Ophthalmology, Ehime University School of Medicine, Japan.
Nippon Ganka Gakkai Zasshi. 1997 Feb;101(2):105-10.
A variety of corneal complications which occur in diabetics were briefly reviewed and the importance of the recognition of diabetic keratopathy was emphasized. This particular disease emerges and persists following the undue stress including intraocular surgery or photocoagulation. A varied degree of epithelial disturbance such as superficial punctate keratopathy, persistent epithelial defect, or recurrent corneal erosion can take place based on suppressed cell division, deturgence of barrier function, deterioration of basal cell adhesion, or decreased corneal sensitivity. Corneal endothelium also exhibits abnormalities in cell morphology including coefficient variation or percentages of hexagonal cells so that corneal edema tends to persist postoperatively. The involvement of the polyol pathway has been implicated in the pathogenesis of these disorders.
本文简要回顾了糖尿病患者中出现的各种角膜并发症，并强调了认识糖尿病性角膜病变的重要性。这种特殊疾病在包括眼内手术或光凝在内的过度应激后出现并持续存在。基于细胞分裂受抑制、屏障功能减退、基底细胞黏附力下降或角膜敏感性降低，可发生不同程度的上皮紊乱，如浅层点状角膜病变、持续性上皮缺损或复发性角膜糜烂。角膜内皮细胞形态也出现异常，包括细胞变异系数或六角形细胞百分比，因此角膜水肿在术后往往持续存在。多元醇途径的参与与这些疾病的发病机制有关。
