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本文引用的文献

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Differences in mannose receptor-mediated uptake of lipoarabinomannan from virulent and attenuated strains of Mycobacterium tuberculosis by human macrophages.人类巨噬细胞对来自结核分枝杆菌强毒株和减毒株的脂阿拉伯甘露聚糖的甘露糖受体介导摄取的差异。
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Mycobacterial lipoarabinomannan recognition requires a receptor that shares components of the endotoxin signaling system.分枝杆菌脂阿拉伯甘露聚糖的识别需要一种与内毒素信号系统共享组分的受体。
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Molecular and cellular basis of interleukin 12 activity in prophylaxis and therapy against infectious diseases.白细胞介素12在预防和治疗传染病中的活性的分子和细胞基础。
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Interleukin-12 production by human monocytes infected with Mycobacterium tuberculosis: role of phagocytosis.结核分枝杆菌感染的人单核细胞产生白细胞介素-12：吞噬作用的作用
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Lipoteichoic acid preparations of gram-positive bacteria induce interleukin-12 through a CD14-dependent pathway.革兰氏阳性菌的脂磷壁酸制剂通过依赖CD14的途径诱导白细胞介素-12。
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Control of natural killer cell-mediated innate resistance against the intracellular pathogen Listeria monocytogenes by gamma/delta T lymphocytes.γ/δ T淋巴细胞对自然杀伤细胞介导的针对细胞内病原体单核细胞增生李斯特菌的天然抗性的调控。
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Differential effects of viable and killed bacteria on IL-12 expression of macrophages.活细菌和死细菌对巨噬细胞白细胞介素-12表达的不同影响。
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Regulation of murine macrophage IL-12 production. Activation of macrophages in vivo, restimulation in vitro, and modulation by other cytokines.小鼠巨噬细胞白细胞介素-12产生的调控。体内巨噬细胞的激活、体外再刺激以及其他细胞因子的调节。
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结核分枝杆菌感染的巨噬细胞分泌白细胞介素-12

Interleukin-12 secretion by Mycobacterium tuberculosis-infected macrophages.

作者信息

Ladel C H, Szalay G, Riedel D, Kaufmann S H

机构信息

Department of Immunology, University of Ulm, Germany.

出版信息

Infect Immun. 1997 May;65(5):1936-8. doi: 10.1128/iai.65.5.1936-1938.1997.

DOI:10.1128/iai.65.5.1936-1938.1997
PMID:9125583
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC175245/
Abstract

Infection with Mycobacterium tuberculosis or phagocytosis of large latex beads induced interleukin-12 (IL-12) production in macrophages. In contrast, tumor necrosis factor (TNF) was produced only in response to M. tuberculosis infection, not after phagocytosis of latex beads. Comparable results were obtained with cells from immunocompetent C57BL/6 and gamma interferon receptor-deficient mutant mice. Thus, phagocytosis by mechanisms not specific for M. tuberculosis was a sufficient trigger for IL-12 secretion, emphasizing the central role of this cytokine in the initiation of anti-infective immunity.

摘要

结核分枝杆菌感染或巨噬细胞吞噬大乳胶珠可诱导白细胞介素-12（IL-12）产生。相比之下，肿瘤坏死因子（TNF）仅在结核分枝杆菌感染时产生，而在吞噬乳胶珠后不产生。免疫功能正常的C57BL/6小鼠和γ干扰素受体缺陷型突变小鼠的细胞也得到了类似结果。因此，通过非特异性针对结核分枝杆菌的机制进行吞噬是IL-12分泌的充分触发因素，这强调了这种细胞因子在抗感染免疫启动中的核心作用。