结核分枝杆菌感染的巨噬细胞分泌白细胞介素-12
Interleukin-12 secretion by Mycobacterium tuberculosis-infected macrophages.
作者信息
Ladel C H, Szalay G, Riedel D, Kaufmann S H
机构信息
Department of Immunology, University of Ulm, Germany.
出版信息
Infect Immun. 1997 May;65(5):1936-8. doi: 10.1128/iai.65.5.1936-1938.1997.
Abstract
Infection with Mycobacterium tuberculosis or phagocytosis of large latex beads induced interleukin-12 (IL-12) production in macrophages. In contrast, tumor necrosis factor (TNF) was produced only in response to M. tuberculosis infection, not after phagocytosis of latex beads. Comparable results were obtained with cells from immunocompetent C57BL/6 and gamma interferon receptor-deficient mutant mice. Thus, phagocytosis by mechanisms not specific for M. tuberculosis was a sufficient trigger for IL-12 secretion, emphasizing the central role of this cytokine in the initiation of anti-infective immunity.
摘要
结核分枝杆菌感染或巨噬细胞吞噬大乳胶珠可诱导白细胞介素-12（IL-12）产生。相比之下，肿瘤坏死因子（TNF）仅在结核分枝杆菌感染时产生，而在吞噬乳胶珠后不产生。免疫功能正常的C57BL/6小鼠和γ干扰素受体缺陷型突变小鼠的细胞也得到了类似结果。因此，通过非特异性针对结核分枝杆菌的机制进行吞噬是IL-12分泌的充分触发因素，这强调了这种细胞因子在抗感染免疫启动中的核心作用。
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本文引用的文献
1
2
Mycobacterial lipoarabinomannan recognition requires a receptor that shares components of the endotoxin signaling system.
J Immunol. 1996 Sep 15;157(6):2549-54.
3
Molecular and cellular basis of interleukin 12 activity in prophylaxis and therapy against infectious diseases.
Mol Med Today. 1996 Jun;2(6):258-67. doi: 10.1016/1357-4310(96)88807-1.
4
Scavenger receptors in innate immunity.
Curr Opin Immunol. 1996 Feb;8(1):20-8. doi: 10.1016/s0952-7915(96)80100-2.
5
Interleukin-12 production by human monocytes infected with Mycobacterium tuberculosis: role of phagocytosis.
Infect Immun. 1996 Jul;64(7):2523-31. doi: 10.1128/iai.64.7.2523-2531.1996.
6
Lipoteichoic acid preparations of gram-positive bacteria induce interleukin-12 through a CD14-dependent pathway.
Infect Immun. 1996 Jun;64(6):1906-12. doi: 10.1128/iai.64.6.1906-1912.1996.
7
Control of natural killer cell-mediated innate resistance against the intracellular pathogen Listeria monocytogenes by gamma/delta T lymphocytes.
Infect Immun. 1996 May;64(5):1744-9. doi: 10.1128/iai.64.5.1744-1749.1996.
8
Differential effects of viable and killed bacteria on IL-12 expression of macrophages.
J Immunol. 1996 Apr 15;156(8):2979-84.
9
The instructive role of innate immunity in the acquired immune response.
Science. 1996 Apr 5;272(5258):50-3. doi: 10.1126/science.272.5258.50.
10
Regulation of murine macrophage IL-12 production. Activation of macrophages in vivo, restimulation in vitro, and modulation by other cytokines.
J Immunol. 1996 Feb 1;156(3):1196-206.
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