Texas Biomedical Research Institute, San Antonio, TX 78227, United States; College of Medicine, The Ohio State University, Columbus, OH 43210, United States.
Texas Biomedical Research Institute, San Antonio, TX 78227, United States.
Exp Gerontol. 2018 May;105:32-39. doi: 10.1016/j.exger.2017.12.021. Epub 2017 Dec 26.
Growing old is associated with an increase in the basal inflammatory state of an individual and susceptibility to many diseases, including infectious diseases. Evidence is growing to support the concept that inflammation and disease susceptibility in the elderly is linked. Our studies focus on the infectious disease tuberculosis (TB), which is caused by Mycobacterium tuberculosis (M.tb), a pathogen that infects approximately one fourth of the world's population. Aging is a major risk factor for developing TB, and inflammation has been strongly implicated. In this review we will discuss the relationship between inflammation in the lung and susceptibility to develop and succumb to TB in old age. Further understanding of the relationship between inflammation, age, and M.tb will lead to informed decisions about TB prevention and treatment strategies that are uniquely designed for the elderly.
衰老是个体基础炎症状态增加和易患许多疾病（包括传染病）的原因。越来越多的证据支持这样一种概念，即老年人的炎症和疾病易感性是相关的。我们的研究集中在传染病结核病（TB）上，它是由结核分枝杆菌（M.tb）引起的，这种病原体感染了世界上大约四分之一的人口。衰老是患结核病的主要危险因素，炎症强烈暗示了这一点。在这篇综述中，我们将讨论肺部炎症与易患和易患老年结核病之间的关系。进一步了解炎症、年龄和 M.tb 之间的关系将导致针对老年人制定独特的结核病预防和治疗策略的明智决策。
