Malaguarnera M, Restuccia S, Di Fazio I, Zoccolo A M, Trovato B A, Pistone G
Istituto di Medicina Interna e Geriatria, Medical School of Catania, Italy.
Dig Dis Sci. 1997 Apr;42(4):762-6. doi: 10.1023/a:1018855928753.
beta2-Microglobulin (beta2-MG) plays a key role in influencing the immune response to viral infections as it is an integrating part of the main histocompatibility system (HLA). We attempted to evaluate the changes in class I HLA antigens by comparing the serum beta2-MG behavior in a group of patients affected by chronic hepatitis C with that observed in a group of healthy controls. Our study revealed that the patients presented higher serum beta2-MG levels than healthy controls (P = 0.0003). beta2-MG levels were correlated with duration and degree of the disease. Furthermore, there was a statistically significant correlation between beta2-MG and HCV RNA levels, while no correlations were observed between serum beta2-MG levels and HCV genotypes. The increment in serum beta2-MG values accompanying the progression of liver disease may be an expression of augmented production rather than altered excretion.
β2微球蛋白（β2-MG）在影响机体对病毒感染的免疫反应中发挥关键作用，因为它是主要组织相容性系统（HLA）的一个组成部分。我们试图通过比较一组慢性丙型肝炎患者血清β2-MG的表现与一组健康对照者血清β2-MG的表现，来评估I类HLA抗原的变化。我们的研究显示，患者的血清β2-MG水平高于健康对照者（P = 0.0003）。β2-MG水平与疾病的持续时间和严重程度相关。此外，β2-MG与HCV RNA水平之间存在统计学上的显著相关性，而血清β2-MG水平与HCV基因型之间未观察到相关性。随着肝病进展血清β2-MG值的升高可能是产量增加而非排泄改变的表现。
