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母乳中一种氯代烃导致的梗阻性黄疸。

Obstructive jaundice due to a chlorinated hydrocarbon in breast milk.

作者信息

Bagnell P C, Ellenberger H A

出版信息

Can Med Assoc J. 1977 Nov 5;117(9):1047-8.

PMID:912629
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1880184/
Abstract

A 6-week-old breast-fed infant had obstructive jaundice and hepatomegaly. When a dry-cleaning solvent, tetrachloroethylene, was detected in the mother's milk and blood, breast-feeding was discontinued. Rapid clinical and biochemical improvement followed. The child grew normally and had normal liver function during 2 years of follow-up.

摘要

一名6周大的母乳喂养婴儿出现阻塞性黄疸和肝肿大。当在母乳和母亲血液中检测到干洗溶剂四氯乙烯时,停止了母乳喂养。随后临床和生化指标迅速改善。在两年的随访期间,孩子生长正常,肝功能也正常。

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本文引用的文献

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Hazardous exposure to some so-called safe solvents.
J Am Med Assoc. 1954 Sep 18;156(3):234-7. doi: 10.1001/jama.1954.02950030026009.
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Liver disease secondary to tetrachloroethylene exposure. A case report.四氯乙烯暴露继发的肝脏疾病。病例报告。
JAMA. 1966 Aug 22;197(8):662-3.
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Actue tetrachloroethylene intoxication.急性四氯乙烯中毒
JAMA. 1969 May 26;208(8):1490-2. doi: 10.1001/jama.208.8.1490.
4
Hepatotoxic potency of various chlorinated hydrocarbon vapours relative to their narcotic and lethal potencies in mice.各种氯代烃蒸气对小鼠的肝毒性效力与其麻醉和致死效力的比较。
Toxicol Appl Pharmacol. 1968 Nov;13(3):287-98. doi: 10.1016/0041-008x(68)90102-6.
5
Considerations of the pathogenesis of neonatal hepatitis, biliary atresia and choledochal cyst--the concept of infantile obstructive cholangiopathy.新生儿肝炎、胆道闭锁和胆总管囊肿发病机制的探讨——婴儿阻塞性胆管病的概念
Prog Pediatr Surg. 1974;6:113-39.
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Management of young infants presenting with direct-reacting hyperbilirubinemia.
Pediatr Clin North Am. 1974 Nov;21(4):777-99. doi: 10.1016/s0031-3955(16)33061-9.
7
Presence of PCB, DDE and DDT in human milk in the provinces of New Brunswick and NOVA Scotia, Canada.
Bull Environ Contam Toxicol. 1974 Sep;12(3):258-67. doi: 10.1007/BF01709117.
8
Chlorinated hydrocarbon insecticides in plasma and milk of pregnant and lactating women.孕妇和哺乳期妇女血浆及乳汁中的氯代烃类杀虫剂。
Arch Environ Health. 1969 Feb;18(2):156-64. doi: 10.1080/00039896.1969.10665387.
9
The effect of maternally inhaled trichloroethylene, perchloroethylene, methyl chloroform, and methylene chloride on embryonal and fetal development in mice and rats.
Toxicol Appl Pharmacol. 1975 Apr;32(1):84-96. doi: 10.1016/0041-008x(75)90197-0.
10
Neonatal nonhemolytic jaundice.新生儿非溶血性黄疸
N Engl J Med. 1975 Jan 23;292(4):194-7. doi: 10.1056/NEJM197501232920406.