Sartono E, Kruize Y C, Kurniawan A, Maizels R M, Yazdanbakhsh M
Department of Parasitology, Leiden University, Netherlands.
J Infect Dis. 1997 May;175(5):1276-80. doi: 10.1086/593701.
In an area in which brugian filariasis is endemic, when cytokine levels were analyzed as a function of clinical status comparing those who were asymptomatic and amicrofilaremic with those who were microfilaremic, it was found that both interferon (IFN)-gamma and interleukin (IL)-5 were suppressed in microfilariae carriers (P < .01 and P < .001, respectively), but IL-4 was unabated. Age had a significant effect on cytokine production in both groups. In asymptomatic amicrofilaremic subjects, IL-4 production was high in young persons and decreased with age, whereas in microfilaremic subjects, IL-4 increased significantly with age. Conversely, IFN-gamma showed a tendency to increase with age in asymptomatic amicrofilaremic subjects but not in microfilaremic subjects. IL-5 decreased significantly with increasing age in both asymptomatic amicrofilaremic and microfilaremic groups. These results indicate that the length of exposure to and infection with filarial parasites can each exert a substantial effect on the cytokine response profiles of host T cell populations.
在布鲁氏丝虫病流行地区，当根据临床状况分析细胞因子水平时，将无症状且无微丝蚴血症者与有微丝蚴血症者进行比较，发现微丝蚴携带者体内的干扰素（IFN）-γ和白细胞介素（IL）-5均受到抑制（分别为P < 0.01和P < 0.001），但IL-4未受影响。年龄对两组的细胞因子产生均有显著影响。在无症状无微丝蚴血症的受试者中，年轻人的IL-4产生量较高，且随年龄增长而降低，而在有微丝蚴血症的受试者中，IL-4随年龄显著增加。相反，在无症状无微丝蚴血症的受试者中，IFN-γ有随年龄增加的趋势，但在有微丝蚴血症的受试者中并非如此。在无症状无微丝蚴血症和有微丝蚴血症的两组中，IL-5均随年龄增长显著降低。这些结果表明，接触丝虫寄生虫的时间长短和感染情况均可对宿主T细胞群体的细胞因子反应谱产生重大影响。
