King C L, Nutman T B
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
Immunol Today. 1991 Mar;12(3):A54-8. doi: 10.1016/S0167-5699(05)80016-7.
The persistence of microfilariae in the blood or skin accompanied by a prominent eosinophilia and elevated serum IgE levels are common features of human infection with filarial parasites. In this review Christopher King and Thomas Nutman discuss recent findings on the role of interleukin 4 (IL-4), IL-5 and gamma-interferon (IFN-gamma) in the induction of these immediate hypersensitivity responses. They discuss the role of hypersensitivity in immunity, the development of immune tolerance to filarial antigens and suggest that could explain the impaired immune response of some individuals to filarial infections and the persistence of the microfilaremic state.
微丝蚴在血液或皮肤中的持续存在，伴有显著的嗜酸性粒细胞增多和血清IgE水平升高，是人类感染丝虫寄生虫的常见特征。在这篇综述中，克里斯托弗·金和托马斯·纳特曼讨论了白细胞介素4（IL-4）、IL-5和γ干扰素（IFN-γ）在诱导这些速发型超敏反应中作用的最新发现。他们讨论了超敏反应在免疫中的作用、对丝虫抗原免疫耐受的发展，并提出这可能解释了一些个体对丝虫感染的免疫反应受损以及微丝蚴血症状态的持续存在。
