训练可改善心力衰竭患者阻力血管的内皮依赖性血管舒张功能。
Training improves endothelium-dependent vasodilation in resistance vessels of patients with heart failure.
作者信息
Katz S D, Yuen J, Bijou R, LeJemtel T H
机构信息
Department of Medicine, Albert Einstein College of Medicine, Bronx 10461, USA.
出版信息
J Appl Physiol (1985). 1997 May;82(5):1488-92. doi: 10.1152/jappl.1997.82.5.1488.
The effects of physical training on endothelium-dependent vasodilation in skeletal muscle resistance vessels were investigated in patients with heart failure. Forearm blood flows (ml.min-1.100 ml-1) in response to brachial arterial administration of acetylcholine (5 x 10(-5) and 5 x 10(-4) M at 1 ml/min) and nitroglycerin (5 x 10(-6) and 5 x 10(-5) M at 1 ml/min) were determined by strain-gauge venous occlusion plethysmography before and after 8 wk of daily handgrip exercise in 12 patients with chronic heart failure. After 8 wk of daily handgrip exercise, the vasodilatory responses to acetylcholine significantly increased from pretraining values, i.e., 16.6 +/- 2.0 vs. 8.6 +/- 1.3 ml.min-1.100 ml-1 (P < 0.05) and 27.5 +/- 1.5 vs. 14.6 +/- 1.7 ml.min-1.100 ml-1 (P < 0.05), respectively, whereas the vasodilatory responses to nitroglycerin did not change. Handgrip exercise training appears to specifically enhance endothelium-dependent vasodilation in the forearm skeletal muscle circulation of patients with heart failure.
在心力衰竭患者中研究了体育锻炼对骨骼肌阻力血管内皮依赖性血管舒张的影响。通过应变片静脉阻塞体积描记法，在12例慢性心力衰竭患者每日进行握力锻炼8周前后，测定肱动脉给予乙酰胆碱（5×10⁻⁵和5×10⁻⁴M，以1ml/min的速度）和硝酸甘油（5×10⁻⁶和5×10⁻⁵M，以1ml/min的速度）后前臂血流量（ml·min⁻¹·100ml⁻¹）。每日握力锻炼8周后，对乙酰胆碱的血管舒张反应较训练前显著增加，即分别为16.6±2.0与8.6±1.3ml·min⁻¹·100ml⁻¹（P<0.05）以及27.5±1.5与14.6±1.7ml·min⁻¹·100ml⁻¹（P<0.05），而对硝酸甘油的血管舒张反应未改变。握力锻炼训练似乎特异性地增强了心力衰竭患者前臂骨骼肌循环中的内皮依赖性血管舒张。
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