van der Linden P J
Department of Obstetrics and Gynecology, Deventer Ziekenhuis, The Netherlands.
Hum Reprod. 1996 Nov;11 Suppl 3:53-65. doi: 10.1093/humrep/11.suppl_3.53.
Although endometriosis has been known for over 100 years, its pathogenesis is still poorly understood. In this overview the literature regarding the pathogenesis of endometriosis is reviewed. The implantation or transplantation theory, that suggests implantation and subsequent growth of retrogradely shed viable endometrial cells, still remains the most widely accepted theory to explain the pathogenesis. The conditions that have to be met for the implantation theory are threefold: (i) retrograde menstruation has to occur; (ii) retrograde menstruation should contain viable endometrial cells; and (iii) adhesion to the peritoneum has to occur with subsequent implantation and proliferation. The scientific data to corroborate these conditions will be discussed. A short overview is given on cell adhesion molecules, in particular cadherins and integrins, the most important cell adhesion molecules involved in cell-cell adhesion and cell-extracellular matrix interaction. Special attention is given to the possible functional role of these cell adhesion molecules in the pathogenesis of endometriosis.
尽管子宫内膜异位症已为人所知达100多年，但对其发病机制仍知之甚少。在本综述中，对有关子宫内膜异位症发病机制的文献进行了回顾。植入或移植理论认为逆行排出的存活子宫内膜细胞发生植入并随后生长，该理论仍是解释发病机制最广泛接受的理论。植入理论必须满足的条件有三个方面：（i）必须发生逆行月经；（ii）逆行月经应包含存活的子宫内膜细胞；（iii）必须发生与腹膜的黏附并随后植入和增殖。将讨论证实这些条件的科学数据。简要概述了细胞黏附分子，特别是钙黏蛋白和整合素，它们是参与细胞间黏附和细胞与细胞外基质相互作用的最重要细胞黏附分子。特别关注这些细胞黏附分子在子宫内膜异位症发病机制中可能的功能作用。
