荷莲豆草（石竹科）镇咳活性的研究。

Studies on antitussive activity of Drymaria cordata Willd. (Caryophyllaceae).

作者信息

Mukherjee P K, Saha K, Bhattacharya S, Giri S N, Pal M, Saha B P

机构信息

Department of Pharmaceutical Technology, Faculty of Engineering and Technology, Jadavpur University, Calcutta, India.

出版信息

J Ethnopharmacol. 1997 Mar;56(1):77-80. doi: 10.1016/s0378-8741(97)01512-2.

DOI:10.1016/s0378-8741(97)01512-2

PMID:9147257

Abstract

The methanol extract of Drymaria cordata Willd. was investigated for its effect on a cough model induced by sulfur dioxide gas in mice. It exhibited significant antitussive activity when compared with the control in a dose-dependent manner. The antitussive activity of the extract was comparable to that of codeine phosphate, a prototype antitussive agent. The D. cordata extract (100, 200, 400 mg/kg) showed 11.6%, 31.6% and 51.5% inhibition of cough with respect to the control group.

摘要

对荷莲豆草（Drymaria cordata Willd.）的甲醇提取物进行了研究，考察其对二氧化硫气体诱发的小鼠咳嗽模型的影响。与对照组相比，它以剂量依赖的方式表现出显著的镇咳活性。该提取物的镇咳活性与磷酸可待因（一种原型镇咳剂）相当。荷莲豆草提取物（100、200、400mg/kg）相对于对照组对咳嗽的抑制率分别为11.6%、31.6%和51.5%。