Hellstedt T, Kaaja R, Teramo K, Immonen I
Department of Ophthalmology, Helsinki University Hospital, Finland.
Graefes Arch Clin Exp Ophthalmol. 1997 Feb;235(2):70-5. doi: 10.1007/BF00941732.
To evaluate the correlation between the changes in contrast sensitivity and retinopathy throughout pregnancy in diabetic women with mild background diabetic retinopathy.
Contrast sensitivity (Vistech 6500 Contrast Test System) was measured in 22 type I diabetic women with mild background retinopathy [0-16 microaneurysms (MAs)/eye and occasional small intraretinal hemorrhages] and 10 healthy pregnant women at the 12th and 32nd weeks of pregnancy and 3 months after delivery. Red-free fundus photography was also performed at all visits.
Throughout pregnancy contrast sensitivity was lower in the diabetics than in the controls at 1.5, 3.0, and 6.0 cycles per degree (cpd). During the course of pregnancy, contrast sensitivity decreased at 1.5 and 6.0 cpd in patients with more than five new MAs compared to those with fewer than five new MAs during pregnancy. Likewise, contrast sensitivity decreased at 6 cpd in patients with an increase in MA count during pregnancy and at 6 and 12 cpd in patients with a baseline MA count of two or more MAs.
Contrast sensitivity, especially at low to mid-range spatial frequencies, is decreased in diabetic women with mild retinopathy. Even small changes in retinopathy are reflected in a decrease in contrast sensitivity during and after pregnancy. Thus, contrast sensitivity seems to be a sensitive indicator of changes in minimal background retinopathy.
评估患有轻度背景性糖尿病视网膜病变的糖尿病女性在整个孕期对比敏感度变化与视网膜病变之间的相关性。
对22例患有轻度背景性视网膜病变的I型糖尿病女性[每只眼有0 - 16个微动脉瘤（MAs）且偶见小的视网膜内出血]和10例健康孕妇在妊娠第12周和第32周以及产后3个月时进行对比敏感度测量（使用Vistech 6500对比测试系统）。每次就诊时还进行无赤眼底照相。
在整个孕期，糖尿病患者在每度1.5、3.0和6.0周期（cpd）时的对比敏感度低于对照组。在孕期，与孕期新增MAs少于5个的患者相比，新增MAs多于5个的患者在1.5和6.0 cpd时对比敏感度下降。同样，孕期MA计数增加的患者在6 cpd时对比敏感度下降，基线MA计数为两个或更多MAs的患者在6和12 cpd时对比敏感度下降。
患有轻度视网膜病变的糖尿病女性的对比敏感度降低，尤其是在低至中等空间频率时。即使视网膜病变有微小变化也会在孕期及产后表现为对比敏感度下降。因此，对比敏感度似乎是微小背景性视网膜病变变化的一个敏感指标。
