Piirilä P, Keskinen H, Anttila S, Hyvönen M, Pfäffli P, Tuomi T, Tupasela O, Tuppurainen M, Nordman H
Finnish Institute of Occupational Health, Helsinki.
Eur Respir J. 1997 Apr;10(4):948-51.
Only one case report concerning allergic alveolitis caused by polyester powder paint has been published previously. The aim of this study was to determine whether phthalic anhydride (PA) or trimellitic anhydride (TMA) is the alveolitis-causing agent in such paint. A 61 year old woman showed recurrent symptoms of chills, cough, and fever whilst at work. She was working in a plant where epoxy polyester powder paints were used to paint metal. The paint was found to contain low (<1%) amounts of TMA and PA. The patient showed shadowing on chest radiographs. In bronchoalveolar lavage, lymphocytosis (67%) and a low T-helper/T-suppressor ratio (0.2) were found. Transfer factor was within normal limits, but a slight reduction was verified after re-exposure to the paint. The symptoms, exposure, reduction in transfer factor, findings on chest radiographs and bronchoalveolar lavage were consistent with allergic alveolitis. In conclusion, the polyester powder paint used in the plant caused allergic alve olitis in this patient. Of the constituents in the paint, trimellitic anhydride and phthalic anhydride were the possible causative agents.
此前仅发表过一篇关于聚酯粉末涂料引起过敏性肺泡炎的病例报告。本研究的目的是确定邻苯二甲酸酐（PA）或偏苯三酸酐（TMA）是否为此类涂料中导致肺泡炎的致病因子。一名61岁女性在工作时反复出现寒战、咳嗽和发热症状。她在一家使用环氧聚酯粉末涂料对金属进行喷漆的工厂工作。经检测，该涂料中TMA和PA的含量较低（<1%）。患者胸部X光片显示有阴影。支气管肺泡灌洗检查发现淋巴细胞增多（67%）且T辅助细胞/T抑制细胞比值较低（0.2）。转移因子在正常范围内，但再次接触该涂料后证实有轻微下降。症状、接触情况、转移因子降低、胸部X光片表现以及支气管肺泡灌洗结果均符合过敏性肺泡炎。总之，该工厂使用的聚酯粉末涂料导致了该患者发生过敏性肺泡炎。涂料中的成分偏苯三酸酐和邻苯二甲酸酐可能是致病因素。
