Harada N, Iwamoto M, Hirosawa I, Nakamoto M, Sobhan F, Morie T, Kosiyama Y
Department of Hygiene, Yamaguchi University School of Medicine, Ube, Japan.
Cent Eur J Public Health. 1995;3 Suppl:54-6.
We investigated urinary catecholamines' response to acute psychological stress test in hand-arm vibration syndrome patients. Thirteen patients with vibration-induced white finger (VWF) in higher frequency of attack, 7 patients with VWF in lower frequency, 6 patients without VWF and 17 healthy subjects were examined. All subjects were male and their average age (SD) was 59.2 (6.4), 56.3 (2.9), 58.2 (4.7) and 56.8 (4.9), respectively. After an initial rest for 1 hour, acute psychological stress test with stressors--mirror drawing, watching horror video and arithmetic under intermittent noise was performed for 1 hour. Subjective complaints to the stress test were greater in patients with hand-arm vibration syndrome than in the healthy controls. The patient group with VWF in higher frequency indicated significant increases of urinary catecholamines (p < 0.05); average values (SD) at rest period and at stress test were 2.42 (1.17) and 3.71 (1.82) micrograms/h for norepinephrine, and 1.47 (0.73) and 2.66 (1.79) micrograms/h for epinephrine, respectively. Increasing tendency of urinary catecholamines was observed in other three groups, however, they were not statistically significant. The sympathoadrenal medullary response to psychological stressors increased especially in hand-arm vibration syndrome patients with VWF in higher frequency.
我们研究了手臂振动综合征患者尿儿茶酚胺对急性心理应激测试的反应。检查了13例发作频率较高的振动性白指（VWF）患者、7例发作频率较低的VWF患者、6例无VWF患者和17名健康受试者。所有受试者均为男性，他们的平均年龄（标准差）分别为59.2（6.4）岁、56.3（2.9）岁、58.2（4.7）岁和56.8（4.9）岁。在最初休息1小时后，进行了为期1小时的急性心理应激测试，应激源包括镜像绘画、观看恐怖视频以及在间歇性噪音下做算术题。手臂振动综合征患者对应激测试的主观不适比健康对照组更严重。发作频率较高的VWF患者组尿儿茶酚胺显著增加（p<0.05）；休息期和应激测试时去甲肾上腺素的平均值（标准差）分别为2.42（1.17）和3.71（1.82）微克/小时，肾上腺素分别为1.47（0.73）和2.66（1.79）微克/小时。其他三组尿儿茶酚胺有增加趋势，但无统计学意义。尤其是发作频率较高的VWF手臂振动综合征患者，其交感肾上腺髓质对应激源的反应增强。
