Harada N
Department of Hygiene, Yamaguchi University School of Medicine, Ube, Japan.
Nagoya J Med Sci. 1994 May;57 Suppl:77-85.
We have investigated the autonomic nervous function of hand-arm vibration syndrome patients using blood chemical analyses and electrophysiological methods. When exposed to whole body cooling, hand-arm vibration syndrome patients showed a significantly greater increase of plasma norepinephrine than the age-matched healthy controls. The patients also exhibited reduced variation of R-R intervals in electrocardiogram during deep breathing. When classifying the subjects according to the Stockholm Workshop scale of VWF, the subjects of stage 3 showed the most remarkable findings followed by the subjects of stage 2. The findings of the stage 3 subjects were also greater than those of diabetes patients. The excess secretion of norepinephrine in blood reveals that the responsiveness of the sympathetic nervous system to cold exposure is enhanced in hand-arm vibration syndrome patients. The R-R interval variation suggests that the basal activity of the parasympathetic nervous system is reduced. We observed that plasma norepinephrine also increased during short-term exposure of hand-arm to vibration and noise exposure potentiated the effect. It seems likely that repeated vibration exposures of the hand-arm system develop the hyperactivity of the sympathetic nervous system.
我们使用血液化学分析和电生理方法研究了手臂振动综合征患者的自主神经功能。当暴露于全身冷却时，手臂振动综合征患者的血浆去甲肾上腺素升高幅度明显大于年龄匹配的健康对照组。患者在深呼吸时心电图的R-R间期变化也减小。根据斯德哥尔摩手部振动病研讨会（VWF）量表对受试者进行分类时，3期受试者的结果最为显著，其次是2期受试者。3期受试者的结果也大于糖尿病患者。血液中去甲肾上腺素的过度分泌表明，手臂振动综合征患者交感神经系统对冷暴露的反应性增强。R-R间期变化表明副交感神经系统的基础活动降低。我们观察到，手臂短期暴露于振动时血浆去甲肾上腺素也会增加，并且噪声暴露会增强这种效应。手臂系统反复暴露于振动似乎会导致交感神经系统功能亢进。
