Le Grevès P, Huang W, Johansson P, Thörnwall M, Zhou Q, Nyberg F
Department of Pharmaceutical Biosciences, Uppsala University,
Neurosci Lett. 1997 Apr 18;226(1):61-4. doi: 10.1016/s0304-3940(97)00244-9.
The expression of the N-methyl-D-aspartate (NMDA) receptor subunits NR1, NR2A and NR2B mRNAs was examined in discrete areas of the male rat brain (including hippocampus, hypothalamus, nucleus accumbens and cortex) following 14 days daily intramuscular injections of high doses (5 and 15 mg/kg) of an anabolic-androgenic steroid (AAS) (nandrolone decanoate). The results indicated that the drug produced a significant decrease in the mRNA expression of the NR2A receptor subunit both in the hypothalamus and hippocampus. A decrease in the level of NR2B receptor mRNA was observed in hypothalamus at the lower dose of the AAS but in other areas examined, this receptor subunit mRNA was not affected. Except for a decreased expression in the nucleus accumbens at the higher dose of AAS the NR1 receptor subunit mRNA was not affected by the drug. The three subunit mRNAs in cortex were not significantly altered. The effects of the steroid on the mRNA expression for the NMDA receptor subunits in hippocampus and hypothalamus are suggested to be involved in the mechanism behind aggressive behaviour, a feature previously associated with AAS misuse. The downregulation of the mRNA for the NR1 receptor subunit in nucleus accumbens may relate to a mechanism involved in the recently suggested AAS-induced stimulation of the brain reward system.
在雄性大鼠脑的离散区域（包括海马体、下丘脑、伏隔核和皮层）中，研究了每日肌肉注射高剂量（5毫克/千克和15毫克/千克）合成代谢雄激素类固醇（AAS）（癸酸诺龙）14天后N-甲基-D-天冬氨酸（NMDA）受体亚基NR1、NR2A和NR2B mRNA的表达情况。结果表明，该药物在下丘脑和海马体中均使NR2A受体亚基的mRNA表达显著降低。在较低剂量的AAS作用下，下丘脑观察到NR2B受体mRNA水平降低，但在其他检测区域，该受体亚基mRNA未受影响。除了在较高剂量的AAS作用下伏隔核中表达降低外，NR1受体亚基mRNA不受该药物影响。皮层中的三种亚基mRNA未发生显著改变。类固醇对海马体和下丘脑NMDA受体亚基mRNA表达的影响被认为与攻击行为背后的机制有关，攻击行为是先前与AAS滥用相关的一个特征。伏隔核中NR1受体亚基mRNA的下调可能与最近提出的AAS诱导的脑奖赏系统刺激所涉及的机制有关。
