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Increased levels of IL-13 mRNA, but not IL-4 mRNA, are found in vivo in peripheral blood mononuclear cells (PBMC) of patients with atopic dermatitis (AD).在特应性皮炎（AD）患者的外周血单个核细胞（PBMC）中，体内可检测到白细胞介素-13（IL-13）信使核糖核酸（mRNA）水平升高，但白细胞介素-4（IL-4）mRNA水平未升高。
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2
In vivo levels of IL-4, IL-10, TGF-beta1 and IFN-gamma mRNA of the peripheral blood mononuclear cells in patients with alopecia areata in comparison to those in patients with atopic dermatitis.斑秃患者外周血单个核细胞中白细胞介素-4、白细胞介素-10、转化生长因子-β1和干扰素-γ信使核糖核酸的体内水平与特应性皮炎患者的比较。
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3
Increased type 2 cytokine expression by both CD4+ CD45RO+ T cells and CD8+ CD45RO+ T cells in blood circulation is associated with high serum IgE but not with atopic dermatitis.血液循环中CD4+ CD45RO+ T细胞和CD8+ CD45RO+ T细胞中2型细胞因子表达增加与高血清IgE相关，但与特应性皮炎无关。
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T cell subsets and cytokines in allergic and non-allergic children. I. Analysis of IL-4, IFN-gamma and IL-13 mRNA expression and protein production.过敏性和非过敏性儿童的T细胞亚群及细胞因子。I.白细胞介素-4、γ干扰素和白细胞介素-13信使核糖核酸表达及蛋白生成的分析
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Peripheral blood mononuclear cells from IgE- and non-IgE-associated allergic atopic eczema/dermatitis syndrome (AEDS) demonstrate increased capacity of generating interleukin-13 but differ in their potential of synthesizing interferon-gamma.来自IgE相关和非IgE相关过敏性特应性皮炎综合征（AEDS）的外周血单个核细胞显示出产生白细胞介素-13的能力增强，但在合成干扰素-γ的潜力方面存在差异。
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In vitro responsiveness to IL-18 in combination with IL-12 or IL-2 by PBMC from patients with bronchial asthma and atopic dermatitis.支气管哮喘和特应性皮炎患者外周血单个核细胞对白细胞介素-18联合白细胞介素-12或白细胞介素-2的体外反应性。
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Pathogenesis of allergen-induced eosinophilic esophagitis is independent of interleukin (IL)-13.变应原诱导的嗜酸性粒细胞性食管炎的发病机制与白细胞介素 (IL)-13 无关。
Immunol Cell Biol. 2013 Jul;91(6):408-15. doi: 10.1038/icb.2013.21. Epub 2013 May 21.
3
The relationship between serum levels of total IgE, IL-18, IL-12, IFN-gamma and disease severity in children with atopic dermatitis.特应性皮炎患儿血清总IgE、IL-18、IL-12、IFN-γ水平与疾病严重程度的关系。
Mediators Inflamm. 2006;2006(4):73098. doi: 10.1155/MI/2006/73098.
4
Differential expression of mRNA for Th1 and Th2 cytokine-associated transcription factors and suppressors of cytokine signalling in peripheral blood mononuclear cells of patients with atopic dermatitis.特应性皮炎患者外周血单个核细胞中Th1和Th2细胞因子相关转录因子及细胞因子信号抑制因子的mRNA差异表达
Clin Exp Immunol. 2004 Mar;135(3):505-10. doi: 10.1111/j.1365-2249.2004.02405.x.
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Methods for the in vitro determination of an individual disposition towards TH1- or TH2-reactivity by the application of appropriate stimulatory antigens.通过应用合适的刺激抗原在体外测定个体对TH1或TH2反应性倾向的方法。
Clin Exp Immunol. 2003 Oct;134(1):78-85. doi: 10.1046/j.1365-2249.2003.02265.x.
6
Increased levels in vivo of mRNAs for IL-8 and macrophage inflammatory protein-1 alpha (MIP-1 alpha), but not of RANTES mRNA in peripheral blood mononuclear cells of patients with atopic dermatitis (AD).特应性皮炎（AD）患者外周血单个核细胞中白细胞介素-8（IL-8）和巨噬细胞炎性蛋白-1α（MIP-1α）的mRNA在体内水平升高，但调节激活正常T细胞表达和分泌的趋化因子（RANTES）mRNA水平未升高。
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7
Intracellular interferon-gamma (IFN-gamma) production in normal children and children with atopic dermatitis.正常儿童和特应性皮炎患儿的细胞内γ干扰素（IFN-γ）产生情况。
Clin Exp Immunol. 1999 Mar;115(3):377-82. doi: 10.1046/j.1365-2249.1999.00814.x.
8
Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production.白细胞介素-13在肺部的表达会引发炎症、黏液分泌过多、上皮下纤维化、生理异常以及嗜酸性粒细胞趋化因子的产生。
J Clin Invest. 1999 Mar;103(6):779-88. doi: 10.1172/JCI5909.
9
The role of IL-13 in IgE synthesis by allergic asthma patients.白细胞介素-13在过敏性哮喘患者免疫球蛋白E合成中的作用。
Clin Exp Immunol. 1998 Jan;111(1):129-35. doi: 10.1046/j.1365-2249.1998.00471.x.

在特应性皮炎（AD）患者的外周血单个核细胞（PBMC）中，体内可检测到白细胞介素-13（IL-13）信使核糖核酸（mRNA）水平升高，但白细胞介素-4（IL-4）mRNA水平未升高。

Increased levels of IL-13 mRNA, but not IL-4 mRNA, are found in vivo in peripheral blood mononuclear cells (PBMC) of patients with atopic dermatitis (AD).

作者信息

Katagiri K, Itami S, Hatano Y, Takayasu S

机构信息

Department of Dermatology, Oita Medical University, Japan.

出版信息

Clin Exp Immunol. 1997 May;108(2):289-94. doi: 10.1046/j.1365-2249.1997.d01-1015.x.

DOI:10.1046/j.1365-2249.1997.d01-1015.x
PMID:9158100
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1904670/
Abstract

Previous studies using in vitro systems with various stimuli have shown that PBMC from patients with AD show increased levels of IL-4 but decreased levels of interferon-gamma (IFN-gamma) compared with PBMC from normal controls. However, in vitro conditions do not always mimic the in vivo condition. We therefore believe that it is important to quantify the expression of these cytokines in freshly isolated PBMC. This study examines the expression of IFN-gamma, IL-4 and IL- 13 mRNA in freshly isolated PBMC from adult patients with AD, from patients with psoriasis vulgaris and from healthy adults, using the semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR) method. Levels of IFN-gamma mRNA were significantly lower in PBMC of patients with AD than in controls. IL-4 mRNA levels did not differ significantly between groups. Conversely, levels of mRNA for IL-13 were significantly greater in PBMC of patients with AD than in controls. An increase in IL-13 expression may regulate the in vivo synthesis of IgE in patients with AD.

摘要

以往使用各种刺激的体外系统进行的研究表明，与正常对照的外周血单核细胞（PBMC）相比，阿尔茨海默病（AD）患者的PBMC中白细胞介素-4（IL-4）水平升高，但干扰素-γ（IFN-γ）水平降低。然而，体外条件并不总是能模拟体内情况。因此，我们认为对外周血单个核细胞中这些细胞因子的表达进行定量很重要。本研究采用半定量逆转录聚合酶链反应（RT-PCR）方法，检测了成年AD患者、寻常型银屑病患者和健康成年人新鲜分离的PBMC中IFN-γ、IL-4和IL-13 mRNA的表达。AD患者PBMC中IFN-γ mRNA水平显著低于对照组。各组间IL-4 mRNA水平无显著差异。相反，AD患者PBMC中IL-13的mRNA水平显著高于对照组。IL-13表达的增加可能调节AD患者体内IgE的合成。