Badgett J T, Hesterberg L K
Department of Pediatrics, University of Louisville School of Medicine, Kentucky 40492, USA.
Microb Drug Resist. 1996 Fall;2(3):371-6. doi: 10.1089/mdr.1996.2.371.
Empirical therapy of presumed group A streptococcus (GAS) pharyngitis leads to unnecessary and inappropriate use of antibiotics and pressure for emergence of resistant strains of common bacteria. Immunoassay technology has produced several rapid tests for GAS. The wide variations in diagnosis and treatment of acute pharyngitis are reviewed including the impact of rapid strep tests. Published studies comparing Strep A OIA to routine agar culture and other rapid strep screens are presented to assess the reliability and applicability of this novel assay. These data suggest that Strep A OIA may be superior to the "gold standard" throat culture and other rapid streptococcal antigen detection assays. Judicious use of Strep A OIA can result in rapid, precise diagnoses and eliminate unnecessary and inappropriate use of antibiotics. Careful antibiotic selection can reduce the pressure for emergence of resistant bacteria. This innovative, effective assay can contribute to a lessening of this serious clinical challenge.
对疑似A组链球菌（GAS）咽炎进行经验性治疗会导致抗生素的不必要和不恰当使用，并促使常见细菌耐药菌株的出现。免疫测定技术已产生了几种针对GAS的快速检测方法。本文综述了急性咽炎诊断和治疗的广泛差异，包括快速链球菌检测的影响。文中展示了已发表的比较A组链球菌OIA与常规琼脂培养及其他快速链球菌筛查的研究，以评估这种新型检测方法的可靠性和适用性。这些数据表明，A组链球菌OIA可能优于“金标准”咽拭子培养及其他快速链球菌抗原检测方法。明智地使用A组链球菌OIA可实现快速、准确的诊断，并消除抗生素的不必要和不恰当使用。谨慎选择抗生素可减轻耐药菌出现的压力。这种创新、有效的检测方法有助于缓解这一严峻的临床挑战。
