Lynch E, Sheerin A, Claxson A W, Atherton M D, Rhodes C J, Silwood C J, Naughton D P, Grootveld M
Department of Conservative Dentistry, St. Bartholomews Hospital School of Medicine and Dentistry, London, U.K.
Free Radic Res. 1997 Mar;26(3):209-34. doi: 10.3109/10715769709097801.
A multicomponent evaluation of the oxidative consumption of salivary biomolecules by a commercially-available oral rinse preparation containing an admixture of the stable free radical species chlorine dioxide (ClO2.) with chlorite anion (ClO2-) has been investigated using high resolution 1H NMR spectroscopy. The results obtained demonstrated that ClO2. and/or ClO2- present in this preparation effected the oxidative decarboxylation of salivary pyruvate (to acetate and CO2). Experiments conducted on chemical model systems confirmed the oxidative decarboxylation of pyruvate by this oral rinse, and also demonstrated that urate, thiocyanate anion, and the amino acids cysteine and methionine (precursors to volatile sulphur compounds responsible for oral malodour), were oxidatively consumed. The biochemical, periodontal and therapeutic significance of the results are discussed.
使用高分辨率1H核磁共振光谱法，对一种市售漱口水制剂中唾液生物分子的氧化消耗进行了多组分评估，该制剂含有稳定自由基二氧化氯（ClO2.）与亚氯酸盐阴离子（ClO2-）的混合物。所得结果表明，该制剂中存在的ClO2.和/或ClO2-导致唾液丙酮酸氧化脱羧（生成乙酸和CO2）。在化学模型系统上进行的实验证实了该漱口水对丙酮酸的氧化脱羧作用，还表明尿酸盐、硫氰酸根阴离子以及氨基酸半胱氨酸和甲硫氨酸（导致口腔异味的挥发性硫化合物的前体）被氧化消耗。讨论了这些结果在生化、牙周和治疗方面的意义。
