de Mello A L, Ferreira E C, Vilas Boas L S, Pannuti C S
Departamento de Medicina Tropical, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brasil.
Rev Inst Med Trop Sao Paulo. 1996 May-Jun;38(3):165-9. doi: 10.1590/s0036-46651996000300001.
The prevalence of antibodies against cytomegalovirus (CMV) and the incidence of CMV infection were tested in 98 children aged 5 to 36 months who attended the day-care center of a University hospital in São Paulo. At the beginning of the study the overall prevalence of anti-CMV IgG antibodies was 44% (43/98). Saliva and/or urine samples were obtained from 38 of the 43 children that were seropositive at the beginning of the study for isolation of the virus, and 52.6% of these children were found to excrete CMV in one of the two materials. Among the 37 children that were initially seronegative from whom it was possible to obtain a new blood sample 6 to 12 months later, 22 (59.5%) presented seroconversion. The rate of viral excretion through urine or saliva from the children that seroconverted was 50%. These results indicate that CMV infection is frequent and occurs early among the children who attend this day-care center. However, controlled studies using molecular epidemiology techniques are needed to define more precisely the role of day-care centers in CMV dissemination.
对圣保罗一所大学医院日托中心的98名5至36个月大的儿童进行了巨细胞病毒（CMV）抗体流行率和CMV感染发病率检测。研究开始时，抗CMV IgG抗体的总体流行率为44%（43/98）。从研究开始时血清学呈阳性的43名儿童中的38名获取了唾液和/或尿液样本以分离病毒，其中52.6%的儿童在这两种样本之一中检测到CMV排出。在最初血清学阴性且6至12个月后有可能获取新血液样本的37名儿童中，22名（59.5%）出现了血清转化。血清转化儿童通过尿液或唾液排出病毒的比例为50%。这些结果表明，CMV感染在该日托中心的儿童中很常见且发生较早。然而，需要使用分子流行病学技术进行对照研究，以更准确地确定日托中心在CMV传播中的作用。
