Low J A
Department of Obstetrics and Gynecology, Queen's University, Kingston, Ontario, Canada.
Am J Obstet Gynecol. 1997 May;176(5):957-9. doi: 10.1016/s0002-9378(97)70385-5.
Evidence of a significant metabolic acidosis, an umbilical artery base deficit > 12 mmol/L, confirms that an asphyxial exposure has occurred. This is observed at delivery in approximately 2% of all pregnancies. Classification of the severity of the asphyxial exposure is difficult because the duration and nature of the exposure and the characteristics of the fetal cardiovascular response to the asphyxia in the affected fetus is usually not known. A classification is proposed in which the exposure to asphyxia is confirmed by a blood gas and acid-base assessment with evidence of a significant metabolic acidosis and the severity is defined by newborn encephalopathy and other organ system complications. Outstanding issues that may enhance this classification are identified.
严重代谢性酸中毒的证据，即脐动脉碱剩余>12 mmol/L，证实发生了窒息暴露。在所有妊娠中，约2%的分娩时可观察到这种情况。由于窒息暴露的持续时间和性质以及受影响胎儿对窒息的心血管反应特征通常未知，因此难以对窒息暴露的严重程度进行分类。本文提出了一种分类方法，即通过血气和酸碱评估确认窒息暴露，并伴有严重代谢性酸中毒的证据，其严重程度由新生儿脑病和其他器官系统并发症来定义。文中还指出了可能改进这种分类方法的突出问题。
