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卧床患者血浆中未明确的抗氧化防御机制:与基础代谢率的可能关系。

Unidentified antioxidant defences of human plasma in immobilized patients: a possible relation to basic metabolic rate.

作者信息

Aejmelaeus R, Ketelä T M, Pirttilä T, Hervonen A, Alho H

机构信息

Laboratory of Neurobiology, Medical School, University of Tampere, Finland.

出版信息

Free Radic Res. 1997 Apr;26(4):335-41. doi: 10.3109/10715769709097813.

DOI:10.3109/10715769709097813
PMID:9167938
Abstract

Plasma total peroxyl radical scavenging capacity was studied in terminal patients who were chronically immobilized because of an acute (stroke) or chronic neurodegenerative disease (Alzheimer's disease). A luminometric assay was used to measure total antioxidant capacity (TRAP). The immobilized patients showed significant decrease in TRAP primarily because of a decrease in the concentration of unknown antioxidants. Our results suggest that human plasma may contain unknown antioxidants, the regulation of which could be related to the basic metabolic rate.

摘要

对因急性(中风)或慢性神经退行性疾病(阿尔茨海默病)而长期卧床的晚期患者的血浆总过氧自由基清除能力进行了研究。采用发光分析法测量总抗氧化能力(TRAP)。卧床患者的TRAP显著降低,主要原因是未知抗氧化剂浓度降低。我们的结果表明,人体血浆可能含有未知抗氧化剂,其调节可能与基础代谢率有关。

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