Sheard P, Lee T B, Tattersall M L
Monogr Allergy. 1977;12:245-8.
FPL 55712, previously reported to be a selective antagonist of SRS-A on the guinea-pig ileum, has now been shown to be similarly selective, though less potent, in its antagonism of contractions induced by SRS-A on in vitro preparations of respiratory smooth muscle (human bronchial strips and guinea-pig tracheal tubes). In vivo, bronchoconstriction induced in guinea-pigs by the endogenous release of SRS-A was partially inhibited by relatively large intravenous doses of FPL 55712 and by inhalation of aerosol compound. FPL 55712 was very rapidly cleared following intravenous administration.
FPL 55712，先前报道在豚鼠回肠上是慢反应物质A（SRS - A）的选择性拮抗剂，现已表明在拮抗SRS - A诱导的体外呼吸平滑肌制剂（人支气管条和豚鼠气管环）收缩方面同样具有选择性，尽管效力较低。在体内，豚鼠因内源性释放SRS - A引起的支气管收缩，可被相对大剂量静脉注射FPL 55712和气雾剂吸入部分抑制。静脉注射后，FPL 55712清除非常迅速。
