Chu M, Truumees I, Mierzwa R, Terracciano J, Patel M, Loebenberg D, Kaminski J J, Das P, Puar M S
Schering-Plough Research Institute, Kenilworth, New Jersey 07003, USA.
J Nat Prod. 1997 May;60(5):525-8. doi: 10.1021/np960737v.
A novel antifungal agent, Sch 54445, was isolated from the fermentation broth of an Actinoplanes species. Sch 54445 was identified as a polycyclic xanthone related to the albofungin family of compounds on the basis of analyses of spectroscopic data. As a broad-spectrum antifungal agent, Sch 54445 exhibits highly potent activities against various yeasts and dermatophytes with MIC values approximately 0.00038 microgram/mL.
一种新型抗真菌剂Sch 54445是从一种游动放线菌属菌种的发酵液中分离出来的。根据光谱数据分析，Sch 54445被鉴定为一种与白僵菌素类化合物相关的多环呫吨酮。作为一种广谱抗真菌剂，Sch 54445对各种酵母和皮肤癣菌表现出高效活性，其最低抑菌浓度值约为0.00038微克/毫升。
