Qian-Cutrone J, Kolb J M, McBrien K, Huang S, Gustavson D, Lowe S E, Manly S P
Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, Connecticut 06492, USA.
J Nat Prod. 1998 Nov;61(11):1379-82. doi: 10.1021/np980234k.
Two new naphthacenequinone glycosides, quanolirones I (1) and II (2) were isolated, together with the known compound galtamycin from the fermentation broth of Streptomyces sp. WC76535. The structures 1 and 2 were established by analysis of their spectroscopic data and by comparison of their data to those of galtamycin. Compounds 1, 2, and galtamycin showed inhibitory activity against HCMV protease with IC50 values of 14, 35, and 52 microM, respectively.
从链霉菌属菌株WC76535的发酵液中分离出两种新的萘并四苯醌糖苷，即喹诺利酮I（1）和II（2），以及已知化合物格尔他霉素。通过对它们的光谱数据进行分析，并将其数据与格尔他霉素的数据进行比较，确定了化合物1和2的结构。化合物1、2和格尔他霉素对人巨细胞病毒蛋白酶均表现出抑制活性，其IC50值分别为14、35和52微摩尔。
