Cladodionen，一种来自海洋来源的枝孢属 OUCMDZ-1635 的细胞毒杂交聚酮化合物。

Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.

Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.

Mar Drugs. 2018 Feb 22;16(2):71. doi: 10.3390/md16020071.

A new hybrid polyketide, cladodionen (), together with a new abscisic acid analogue, cladosacid (), were isolated from the marine-derived fungus, sp. OUCMDZ-1635. Their structures, including the absolute configurations, were fully elucidated on the basis of spectroscopic analysis, ECD spectra, quantum chemical calculations, and chemical methods. Cladodionen () showed cytotoxic activities against MCF-7, HeLa, HCT-116, and HL-60 human cancer cell lines with IC values of 18.7, 19.1, 17.9, and 9.1 µM.

从海洋来源的真菌 sp. OUCMDZ-1635 中分离得到了一种新的杂合聚酮化合物 cladodionen () 和一种新的脱落酸类似物 cladosacid ()。基于光谱分析、ECD 光谱、量子化学计算和化学方法，阐明了它们的结构，包括绝对构型。Cladodionen () 对 MCF-7、HeLa、HCT-116 和 HL-60 人癌细胞系表现出细胞毒性，IC 值分别为 18.7、19.1、17.9 和 9.1 μM。