Araneta M R, Moore C A, Olney R S, Edmonds L D, Karcher J A, McDonough C, Hiliopoulos K M, Schlangen K M, Gray G C
Naval Health Research Center, Division of Clinical Epidemiology, San Diego, California 92186-5122, USA.
Teratology. 1997 Oct;56(4):244-51. doi: 10.1002/(SICI)1096-9926(199710)56:4<244::AID-TERA3>3.0.CO;2-Z.
Reports in the popular press described the occurrence of Goldenhar syndrome among children of Persian Gulf War veterans (GWVs). The objective of this investigation was to compare the birth prevalence of Goldenhar syndrome among infants born in military hospitals to GWVs and to military personnel who were not deployed to the Gulf War (NDVs). Computerized hospital discharge data were reviewed for infants conceived after the war and born prior to the 1st of October, 1993, in medical treatment facilities (MTFs) operated by the U.S. Department of Defense. Medical records were evaluated for infants diagnosed at birth with at least one abnormality that might be related to Goldenhar syndrome. Two pediatricians, blinded to the parental Gulf War status of each infant, reviewed records. An estimated 75,414 infants were conceived after the Gulf War and born in MTFs during the study period (34,069 GWV infants and 41,345 NDV infants). Seven infants fulfilled the case criteria (five GWV infants and two NDV infants). All infants had fathers who served in the military at the time of their conception and birth. The birth prevalence was 14.7 per 100,000 live births among GWV infants (95% confidence interval [CI]: 5.4-36.4) and 4.8 per 100,000 live births (95% CI: 0.8-19.5) among NDV infants (relative risk: 3.03; 95% CI: 0.63-20.57; P values: [2-tailed] = 0.26, [1-tailed] = 0.16). The few affected cases and the broad confidence intervals surrounding the relative risk require that these results be interpreted with caution and do not exclude chance as an explanation for these findings.
大众媒体报道了海湾战争退伍军人（GWVs）子女中出现的Goldenhar综合征。本调查的目的是比较在军事医院出生的婴儿中，GWVs子女与未被部署到海湾战争的军事人员（NDVs）子女中Goldenhar综合征的出生患病率。回顾了美国国防部运营的医疗设施（MTFs）中，战后受孕并于1993年10月1日前出生的婴儿的计算机化出院数据。对出生时被诊断患有至少一种可能与Goldenhar综合征相关异常的婴儿的病历进行了评估。两位儿科医生在不知道每个婴儿父母海湾战争状态的情况下审查了病历。在研究期间，估计有75414名婴儿战后受孕并在MTFs出生（34069名GWVs婴儿和41345名NDVs婴儿）。7名婴儿符合病例标准（5名GWVs婴儿和2名NDVs婴儿）。所有婴儿的父亲在其受孕和出生时都在军队服役。GWVs婴儿的出生患病率为每10万例活产14.7例（95%置信区间[CI]：5.4 - 36.4），NDVs婴儿为每10万例活产4.8例（95%CI：0.8 - 19.5）（相对风险：3.03；95%CI：0.63 - 20.57；P值：[双侧] = 0.26，[单侧] = 0.16）。受影响的病例较少以及相对风险周围较宽的置信区间要求对这些结果进行谨慎解释，并且不能排除这些发现是偶然因素导致的可能性。
