Bartel T, Müller S, Schürger D, Gassmann B, Rüttermann V, Erbel R
Zentrum für Innere Medizin, Abteilung Kardiologie, Essen.
Z Kardiol. 1997 Feb;86(2):131-7. doi: 10.1007/s003920050043.
Quantitative tissue Doppler echocardiography is a new diagnostic approach to left ventricular systolic performance. The aim of the present study was to validate a recently developed method based on the computer software TDI-Labor enabling a variable time and space related measurement of regional wall velocity from tissue Doppler images. Therefore, in 63 volunteers the mean velocity of a 2 mm thick subendocardial slice during the systolic ejection period was determined from frozen tissue Doppler M-mode images of the left ventricular posterior wall obtained using the left parasternal window. The same images were employed for comparative measurement of the mean endocardial velocity using the conventional M-mode slope approach. Tissue Doppler data of the subendocardial wall velocity were found to correspond closely to the mean endocardial wall velocity (y = 0.97x + 0.17; r = 0.77; p < 0.0001). The average wall motion gradient of the population was 1.33 +/- 0.35. Wall motion velocity and wall motion gradient were shown to be not age dependent. The new software approach to an improved analysis of wall motion offering any sized sample volumes and time intervals for wall velocity measurements can be regarded as an exact and easily feasible method. Further clinical and experimental investigations are needed to evaluate its diagnostic relevance to the detection of ischemia and other myocardial dysfunction.
定量组织多普勒超声心动图是一种用于评估左心室收缩功能的新型诊断方法。本研究的目的是验证一种最近开发的基于计算机软件TDI-Labor的方法，该方法能够从组织多普勒图像中对区域壁速度进行与时间和空间相关的可变测量。因此，在63名志愿者中，使用左胸骨旁窗获取左心室后壁的冻结组织多普勒M型图像，测定收缩期射血期2毫米厚的心内膜下切片的平均速度。使用传统的M型斜率法对相同图像进行心内膜平均速度的对比测量。发现心内膜下壁速度的组织多普勒数据与心内膜平均壁速度密切相关（y = 0.97x + 0.17；r = 0.77；p < 0.0001）。该人群的平均壁运动梯度为1.33 +/- 0.35。壁运动速度和壁运动梯度显示与年龄无关。这种新的软件方法可改进壁运动分析，为壁速度测量提供任意大小的样本体积和时间间隔，可被视为一种准确且易于实施的方法。需要进一步的临床和实验研究来评估其对检测缺血和其他心肌功能障碍的诊断相关性。
