Kafatos A, Diacatou A, Voukiklaris G, Nikolakakis N, Vlachonikolis J, Kounali D, Mamalakis G, Dontas A S
Department of Social Medicine, University of Crete School of Medicine, Iraklion, Greece.
Am J Clin Nutr. 1997 Jun;65(6):1882-6. doi: 10.1093/ajcn/65.6.1882.
A follow-up study was conducted to identify the heart disease risk-factor status and dietary changes of surviving elderly subjects in Crete who took part in the Seven Countries Study in 1960. In 1991, data were obtained from 245 of the 686 original male participants (169 of the original 40-49-y age group and 76 men 50-59 y age group). In 1991, the men were 70-79 and 80-89 y old. There was a significant (11.5%) increase in serum total cholesterol concentrations between 1960 and 1991. Body mass index and systolic and diastolic blood pressures also increased significantly, and all age groups were characterized by central obesity. A representative subsample of 21 men took part in a 3-d weighed food record study. Dietary data indicated increases in the intake of saturated fat and decreases in monounsaturated fat over the 30-y period. Comparison with a 1962 representative Cretan sample indicated a significantly increased concentration of adipose palmitic acid (16:0) in our surviving sample. The observed changes occurred during a period when many developed countries were observing a decline in most heart disease risk factors.
开展了一项随访研究，以确定1960年参与七国研究的克里特岛老年幸存者的心脏病风险因素状况和饮食变化。1991年，从686名男性原始参与者中的245人（原始40 - 49岁年龄组中的169人以及50 - 59岁年龄组中的76人）获取了数据。1991年时，这些男性年龄在70 - 79岁和80 - 89岁之间。1960年至1991年间，血清总胆固醇浓度显著升高（11.5%）。体重指数以及收缩压和舒张压也显著升高，所有年龄组均以中心性肥胖为特征。21名男性的代表性子样本参与了一项为期3天的称重食物记录研究。饮食数据表明，在这30年期间，饱和脂肪摄入量增加，单不饱和脂肪摄入量减少。与1962年克里特岛代表性样本相比，我们的存活样本中脂肪棕榈酸（16:0）浓度显著升高。观察到的这些变化发生在许多发达国家多数心脏病风险因素呈下降趋势的时期。
