德国新生儿症状性血栓栓塞症：两年调查
Neonatal symptomatic thromboembolism in Germany: two year survey.
作者信息
Nowak-Göttl U, von Kries R, Göbel U
机构信息
Department of Paediatrics, University Hospital of Münster, Germany.
出版信息
Arch Dis Child Fetal Neonatal Ed. 1997 May;76(3):F163-7. doi: 10.1136/fn.76.3.f163.
AIMS
To determine the incidence of neonatal thromboembolism in Germany.
METHODS
Diagnostic imaging techniques, therapeutic modalities, and short term outcome were evaluated in a prospective nationwide two year case registry study.
RESULTS
The reported incidence of symptomatic neonatal thromboembolism, diagnosed in most cases with Doppler ultrasonography, was 5.1 per 100000 births, with a total of 79 cases registered: renal venous thrombosis (n = 35); venous thrombosis (n = 25); and arterial vascular occlusion (n = 19). Fifty seven of 79 thromboses were associated with additional risk factors (central line n = 25, asphyxia n = 13, septicaemia n = 11, dehydration n = 6, maternal diabetes n = 2, cardiac disease n = 1). Inherited thrombophilia was also diagnosed in seven out of 35 cases investigated. Twenty three children received supportive treatment: 42 received heparin and in 13 neonates thrombolytic agents were administered. Most neonates (91%) survived; seven died.
CONCLUSION
Controlled multicentre studies are needed to obtain more information on treatment efficacy.
目的
确定德国新生儿血栓栓塞的发病率。
方法
在一项为期两年的全国性前瞻性病例登记研究中，对诊断成像技术、治疗方式和短期结局进行评估。
结果
报告的有症状新生儿血栓栓塞的发病率为每100000例出生5.1例，大多数病例通过多普勒超声诊断，共登记79例：肾静脉血栓形成（n = 35）；静脉血栓形成（n = 25）；动脉血管闭塞（n = 19）。79例血栓形成中有57例与其他危险因素相关（中心静脉导管n = 25，窒息n = 13，败血症n = 11，脱水n = 6，母亲糖尿病n = 2，心脏病n = 1）。在35例接受调查的病例中，有7例也被诊断为遗传性血栓形成倾向。23名儿童接受了支持性治疗：42名接受了肝素治疗，13名新生儿接受了溶栓药物治疗。大多数新生儿（91%）存活；7例死亡。
结论
需要进行对照多中心研究以获取更多关于治疗效果的信息。
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