Machida N, Taniguchi T, Nakamura T, Kiryu K
Department of Veterinary Pathology, Tokyo University of Agriculture and Technology, Japan.
J Comp Pathol. 1997 May;116(4):379-85. doi: 10.1016/s0021-9975(97)80054-0.
Twenty-five aborted equine fetuses infected with equid herpesvirus 1 (EHV-1) were examined cardio-histopathologically. The main changes in the heart consisted of interstitial myocarditis and intramyocardial vascular lesions accompanied by degeneration and necrosis of the cardiac myocytes. Vascular pathology of intramyocardial small arteries and arterioles was characterized by endothelial cell necrosis and fibrinoid changes in the media. Eosinophilic intranuclear inclusion bodies characteristic of herpesvirus infection were detected in the myocardial cells and macrophages within and around the inflammatory lesions and in the endothelial cells and medial smooth muscle cells of the damaged vessels. This observation, taken in conjunction with the fact that EHV-1 antigens were detected immunohistochemically in some myocardial and endothelial cells, provides morphological evidence in support of the viral aetiology of the cardiac lesions.
对25例感染马疱疹病毒1型（EHV-1）的流产马胎儿进行了心脏组织病理学检查。心脏的主要变化包括间质性心肌炎和心肌内血管病变，并伴有心肌细胞变性和坏死。心肌内小动脉和微动脉的血管病变特征为内皮细胞坏死和中膜纤维蛋白样改变。在炎症病变内及周围的心肌细胞和巨噬细胞以及受损血管的内皮细胞和中膜平滑肌细胞中检测到疱疹病毒感染特有的嗜酸性核内包涵体。这一观察结果，结合免疫组织化学在一些心肌细胞和内皮细胞中检测到EHV-1抗原的事实，为心脏病变的病毒病因提供了形态学证据。
