Doussard-Roosevelt J A, Porges S W, Scanlon J W, Alemi B, Scanlon K B
Institute for Child Study, University of Maryland, College Park, 20742-1131, USA.
Child Dev. 1997 Apr;68(2):173-86.
To investigate heart rate and respiratory sinus arrhythmia (RSA) as markers of developmental outcome, infant ECG and 3 year outcome were assessed in 41 very low birth weight (< 1,500 g) infants. Measures of mean heart rate and RSA, and the maturational shifts in their values from 33 to 35 weeks gestational age, were recorded. RSA measures predicted 3 year outcome beyond the effects of birth weight, medical risk, and socioeconomic status. Higher RSA was associated with better social skills, whereas greater RSA maturation was associated with better mental processing and gross motor skills. Lower heart rate was associated with better behavior regulation and social skills, whereas greater maturational decreases were associated with better gross motor skills. Dividing the sample into groups of infants with birth weights less than 1,000 g and those with birth weights over 1,000 g, RSA maturation emerged a strong predictor of mental processing, knowledge base, and gross motor skills in the former. A measure of joint maturation of RSA and heart rate was associated with better behavior regulation at 3 years, as measured by Child Behavior Checklist and Parenting Stress Index scores, for this group. The findings directly respond to the need for physiological variables in the prediction of outcome in high-risk infants.
为了研究心率和呼吸性窦性心律不齐（RSA）作为发育结局的标志物，对41名极低出生体重（<1500克）婴儿的婴儿心电图和3岁时的结局进行了评估。记录了平均心率和RSA的测量值，以及它们在孕龄33至35周时的成熟度变化。RSA测量值预测了3岁时的结局，超出了出生体重、医疗风险和社会经济地位的影响。较高的RSA与更好的社交技能相关，而更大的RSA成熟度与更好的心理加工和大运动技能相关。较低的心率与更好的行为调节和社交技能相关，而更大的成熟度下降与更好的大运动技能相关。将样本分为出生体重小于1000克的婴儿组和出生体重大于1000克的婴儿组，RSA成熟度在前一组中是心理加工、知识库和大运动技能的有力预测指标。对于该组，通过儿童行为检查表和育儿压力指数评分测量，RSA和心率的联合成熟度指标与3岁时更好的行为调节相关。这些发现直接回应了在预测高危婴儿结局时对生理变量的需求。
