Warwick R O, Bousquet W F, Schnell R C
Pharmacology. 1977;15(5):415-27. doi: 10.1159/000136718.
The effect of morphine on uptake of serotonin into hypothalamic synaptosomes was determined following acute and chronic morphine treatment in the rat. The uptake of serotonin was noncompetitively inhibited by in vitro morphine (IC50 = 7 X 10(-4) M) but not by an acute morphine treatment (30 mg/kg s.c.) which produces hypothermia. Uptake of serotonin into hypothalamic synaptosomes derived from rats rendered tolerant to the hypothermic effect of morphine or rats withdrawn from morphine was not altered either in the absence or presence of in vitro morphine as compared to control rats. These data indicate that alterations in thermoregulatory responses of the rat to either acute or chronic morphine treatment do not result from morphine-induced modification of serotonin uptake into hypothalamic neurons.
在大鼠中进行急性和慢性吗啡处理后，测定了吗啡对下丘脑突触体摄取5-羟色胺的影响。体外吗啡对5-羟色胺的摄取具有非竞争性抑制作用（IC50 = 7×10⁻⁴ M），但产生体温过低的急性吗啡处理（30 mg/kg皮下注射）则无此作用。与对照大鼠相比，来自对吗啡体温过低作用产生耐受的大鼠或已停用吗啡的大鼠的下丘脑突触体，无论在有无体外吗啡的情况下，其5-羟色胺摄取均未改变。这些数据表明，大鼠对急性或慢性吗啡处理的体温调节反应改变并非由吗啡诱导的下丘脑神经元5-羟色胺摄取改变所致。
