Zechner R
SFB Biomembrane Research Center, Institute of Medical Biochemistry, Kari-Franzens-University Graz, Austria.
Curr Opin Lipidol. 1997 Apr;8(2):77-88. doi: 10.1097/00041433-199704000-00005.
The dual function of lipoprotein lipase as a triglyceride hydrolase and a ligand/bridging factor for receptor-mediated lipoprotein uptake implies an important role of the enzyme in the distribution of fatty acids and lipoproteins among extrahepatic tissues. Observations in humans and, more recently, in several induced mutant mouse strains have provided important insights on how fat calories and lipids are partitioned to storage or energy production through the tissue-specific regulation of lipoprotein lipase in adipose tissue and muscle. Imbalances of the tissue-specific expression of lipoprotein lipase were recognized as potentially important effectors of lipoprotein metabolism, energy homeostasis and body weight regulation.
脂蛋白脂肪酶作为甘油三酯水解酶以及受体介导的脂蛋白摄取的配体/桥接因子的双重功能，意味着该酶在肝外组织间脂肪酸和脂蛋白的分布中起重要作用。对人类以及最近对几种诱导突变小鼠品系的观察，为脂肪热量和脂质如何通过脂肪组织和肌肉中脂蛋白脂肪酶的组织特异性调节分配至储存或能量产生过程提供了重要见解。脂蛋白脂肪酶组织特异性表达的失衡被认为是脂蛋白代谢、能量稳态和体重调节的潜在重要效应因素。
