Borman R A, Burleigh D E
Department of Pharmacology, Queen Mary & Westfield College, University of London, United Kingdom.
Ann N Y Acad Sci. 1997 May 30;812:224-5. doi: 10.1111/j.1749-6632.1997.tb48183.x.
In conclusion, application of 5-HT has been shown to induce fluid secretion in both the small and large intestine of man. By the use of selective antagonists, the receptors mediating these effects have been identified and characterized. 5-HT induces secretion across human ileal mucosa via a receptor of the 5-HT4 sub-type, whereas a receptor of the 5-HT2A sub-type appears to mediate the effect in human sigmoid colon. The response in human ascending colonic mucosa cannot be definitively classified at this time, but may reflect the presence of a heterogenous receptor population.
总之，已证明5-羟色胺（5-HT）的应用可在人的小肠和大肠中诱导液体分泌。通过使用选择性拮抗剂，介导这些作用的受体已得到鉴定和表征。5-HT通过5-HT4亚型受体诱导跨人回肠粘膜的分泌，而5-HT2A亚型受体似乎介导了在人乙状结肠中的作用。人升结肠粘膜中的反应目前尚不能明确分类，但可能反映了存在异质性受体群体。
