二氯亚甲基二膦酸盐（氯膦酸盐）对基质金属蛋白酶-1的抑制作用。
Inhibition of matrix metalloproteinase-1 by dichloromethylene bisphosphonate (clodronate).
作者信息
Teronen O, Konttinen Y T, Lindqvist C, Salo T, Ingman T, Lauhio A, Ding Y, Santavirta S, Valleala H, Sorsa T
机构信息
Department of Oral and Maxillofacial Surgery, Institute of Dentistry, University of Helsinki, P.O. Bos 41 (Mannerheimintie 172) FIN-00014, Helsinki, Finland.
出版信息
Calcif Tissue Int. 1997 Jul;61(1):59-61. doi: 10.1007/s002239900295.
Interstitial collagenase present in human jaw cyst extract and purified human fibroblast-type collagenase (MMP-1) were both efficiently inhibited in vitro by clodronate, an osteoactive, antiresorptive bisphosphonate. The IC50 of clodronate to inhibit MMP-1 is 150 microM. These findings suggest an extended and hitherto undescribed properties for clodronate/biphosphonates in prevention and treatment of tissue degradation in both bone and soft tissue destructive diseases.
人颌骨囊肿提取物中存在的间质胶原酶和纯化的人成纤维细胞型胶原酶（基质金属蛋白酶-1）在体外均被氯膦酸盐有效抑制，氯膦酸盐是一种具有骨活性的抗吸收双膦酸盐。氯膦酸盐抑制基质金属蛋白酶-1的IC50为150微摩尔。这些发现表明氯膦酸盐/双膦酸盐在预防和治疗骨及软组织破坏性疾病中的组织降解方面具有扩展的、迄今未被描述的特性。
Zotero 插件