Harari D, Sarkarati M, Gurwitz J H, McGlinchey-Berroth G, Minaker K L
Division on Aging, Harvard Medical School, Boston, MA, USA.
Spinal Cord. 1997 Jun;35(6):394-401. doi: 10.1038/sj.sc.3100417.
To determine the prevalence of constipation-related symptoms in individuals with chronic spinal cord injury (SCI), to describe the bowel program as reported by patients and including use of bowel medications and evacuation techniques, and to examine the clinical, functional and pharmacological risks of difficulty with evacuation.
This is a cross-sectional study of all in-patients at least 3 months beyond acute injury, on the West Roxbury/Brockton VAMC SCI Service, during a 10 month period (n = 197). Clinical, functional, and medication data were abstracted from medical and nursing records. Individual interviews were conducted with all available participants (n = 161, 82%) regarding bowel-related symptoms and treatment over the previous 1 month period. The study definition of difficulty with evacuation was spending more than 1 h per episode of bowel evacuation.
Forty-one percent of the 161 interview responders spent more than 1 h on bowel evacuation, 50% reported abdominal distension and 38% reported abdominal pain, 27% reported headaches or sweats relieved by having a bowel movement, and 33% reported fecal incontinence at least once a month. The bisacodyl suppository was the most commonly used laxative agent, while docusate was the most popular oral agent. Subjects with difficulty with evacuation (n = 66) were compared with those who spent less than 1 h on evacuation (n = 95). Factors associated with difficulty with evacuation were tetraplegia, Frankel grade A/B, laxative use, polypharmacy, previous urinary outlet surgery, and symptoms of abdominal pain and distension.
Constipation-related symptoms are highly prevalent in individuals with spinal cord injury, despite considerable laxative use. Our findings suggest that difficulty with evacuation can be predicted on the basis of a patient's clinical profile.
确定慢性脊髓损伤(SCI)患者中便秘相关症状的患病率,描述患者报告的肠道护理方案,包括肠道药物的使用和排便技巧,并研究排便困难的临床、功能和药理学风险。
这是一项横断面研究,研究对象为在10个月期间(n = 197)入住西罗克斯伯里/布罗克顿退伍军人事务医疗中心SCI科室、急性损伤后至少3个月的所有住院患者。从医疗和护理记录中提取临床、功能和用药数据。对所有可用参与者(n = 161,82%)进行了关于前1个月期间肠道相关症状和治疗的个人访谈。排便困难的研究定义为每次排便时间超过1小时。
161名接受访谈的受访者中,41%的人排便时间超过1小时,50%的人报告有腹胀,38%的人报告有腹痛,27%的人报告排便后头痛或出汗缓解,33%的人报告每月至少有一次大便失禁。比沙可啶栓剂是最常用的泻药,而多库酯是最受欢迎的口服药物。将排便困难的受试者(n = 66)与排便时间少于1小时的受试者(n = 95)进行比较。与排便困难相关的因素包括四肢瘫痪、Frankel A/B级、使用泻药、多种药物治疗、既往尿路手术以及腹痛和腹胀症状。
尽管大量使用泻药,但便秘相关症状在脊髓损伤患者中仍然非常普遍。我们的研究结果表明,排便困难可以根据患者的临床特征进行预测。