Iida T, Hirakawa H, Matsueda T, Nakamura M, Hori T
Fukuoka Institute of Health and Environmental Sciences, Japan.
Fukuoka Igaku Zasshi. 1997 May;88(5):186-92.
We previously reported that high risk environmental contaminants such as polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and coplanar polychlorinated biphenyls (PCBs) are excreted not only in feces but also in the sebum of the face and body in both normal subjects and Yusho patients. A combination of administration of rice bran fiber and cholestyramine increased fecal excretion of PCDFs and PCBs. In the present study, we stimulated excretion of these compounds in sebum using a ceramic sand bath, a kind of sand bath using small ceramic balls (3.5 mm diameter) instead of natural sand. Five normal volunteers participated in this experiment. Sebum eliminated from the body on bathing ceramic sand bath was collected and weighed and then concentrations of the compounds interest in the sebum were determined. We also examined the effects varying the bath conditions such as temperature of sand, length of bathing time and frequency of taking bath on the amounts of the compounds in the eliminated sebum. The results can be summarized as follows: 1. The average amount of sebum per one bath eliminated from the body during the ceramic sand bath was 0.252 g, and those of PCDDs, PCDFs and coplanar PCBs in it were 2.2, 2.0 and 2.2 pg of TEQ (2,3,7,8-tetrachlorodibenzo-p-dioxin equivalent quantity). It was considered that the amounts of these compounds corresponded to between one quarter and third of those eliminated through the sebum in a day. On the other hand, 0.05 g of the sebum was collected from the face during the bath, included 0.39, 0.39 and 0.59 pg TEQ for PCDDs, PCDFs and coplanar PCBs, respectively. 2. As the number of bathing times a day increased, the amount of sebum per bath gradually decreased. However, we could not determine the influence of the conditions of the bath such as temperature and time.
我们之前报道过，多氯代二苯并 - 对 - 二噁英（PCDDs）、多氯代二苯并呋喃（PCDFs）和共平面多氯联苯（PCBs）等高风险环境污染物在正常受试者和 Yusho 病患者的粪便以及面部和身体的皮脂中均有排泄。米糠纤维和消胆胺联合给药可增加 PCDFs 和 PCBs 的粪便排泄量。在本研究中，我们使用陶瓷砂浴来刺激这些化合物在皮脂中的排泄，陶瓷砂浴是一种使用小陶瓷球（直径 3.5 毫米）而非天然砂的砂浴。五名正常志愿者参与了该实验。收集并称重沐浴陶瓷砂浴时从身体上清除的皮脂，然后测定皮脂中目标化合物的浓度。我们还研究了改变浴条件（如砂的温度、沐浴时间长度和沐浴频率）对清除的皮脂中化合物量的影响。结果总结如下：1. 在陶瓷砂浴期间，每次沐浴从身体上清除的皮脂平均量为 0.252 克，其中 PCDDs、PCDFs 和共平面 PCBs 的量分别为 2.2、2.0 和 2.2 皮克毒性当量（2,3,7,8 - 四氯二苯并 - 对 - 二噁英当量）。据认为，这些化合物的量相当于一天中通过皮脂排泄量的四分之一到三分之一。另一方面，沐浴期间从面部收集到 0.05 克皮脂，其中 PCDDs、PCDFs 和共平面 PCBs 分别含有 0.39、0.39 和 0.59 皮克毒性当量。2. 随着一天中沐浴次数的增加，每次沐浴的皮脂量逐渐减少。然而，我们无法确定浴条件（如温度和时间）的影响。
