油症患者血液中多氯联苯、多氯二苯并呋喃和多氯二苯并二噁英的浓度及其毒性当量贡献。
Concentrations of PCBs, PCDFs and PCDDs in the blood of Yusho patients and their toxic equivalent contribution.
作者信息
Masuda Y, Schecter A, Päpke O
机构信息
Daiichi College of Pharmaceutical Sciences, Fukuoka, Japan.
出版信息
Chemosphere. 1998 Oct-Nov;37(9-12):1773-80. doi: 10.1016/s0045-6535(98)00242-2.
Yusho blood and control serum were collected in around 1991 and analyzed for congeners of PCDDs, PCDFs and PCBs. In Yusho blood, TEQ was mainly contributed by 2,3,4,7,8-penta-CDF (77-248 ppt), 1,2,3,4,7,8-hexa-CDF (15-37 ppt) and 2,3,3',4,4',5-hexa-CB (16-77 ppt). Total TEQ in Yusho blood (185-441 ppt) was only 3-14 times higher than that of control serum (31-61 ppt). It is notable that the concentrations of 3,3',4,4',5-, 2,3,3',4,4'- and 2,3',4,4',5-penta-CBs in Yusho blood were comparable to or lower up to 3-5 times than those in control blood.
1991年左右收集了油症患者血液和对照血清，并对其中的多氯二苯并二噁英（PCDDs）、多氯二苯并呋喃（PCDFs）和多氯联苯（PCBs）同系物进行了分析。在油症患者血液中，毒性当量（TEQ）主要由2,3,4,7,8-五氯二苯并呋喃（77 - 248皮克/升）、1,2,3,4,7,8-六氯二苯并呋喃（15 - 37皮克/升）和2,3,3',4,4',5-六氯联苯（16 - 77皮克/升）贡献。油症患者血液中的总TEQ（185 - 441皮克/升）仅比对照血清（31 - 61皮克/升）高3 - 14倍。值得注意的是，油症患者血液中3,3',4,4',5-、2,3,3',4,4'-和2,3',4,4',5-五氯联苯的浓度与对照血液中的浓度相当，或比对照血液中的浓度低3 - 5倍。
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