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本文引用的文献

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Molecular markers reveal that population structure of the human pathogen Candida albicans exhibits both clonality and recombination.分子标记显示，人类病原体白色念珠菌的种群结构既表现出克隆性又存在重组现象。
Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12473-7. doi: 10.1073/pnas.93.22.12473.
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Use of polymorphic short and clustered coding-region microsatellites to distinguish strains of Candida albicans.使用多态性短串联编码区微卫星来区分白色念珠菌菌株。
FEMS Immunol Med Microbiol. 1996 Sep;15(2-3):73-9. doi: 10.1111/j.1574-695X.1996.tb00056.x.
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Molecular probe for typing strains of Candida albicans.用于白色念珠菌菌株分型的分子探针。
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Long, polymorphic microsatellites in simple organisms.简单生物体中的长串联重复多态微卫星序列
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Secular trends in the epidemiology of nosocomial fungal infections in the United States, 1980-1990. National Nosocomial Infections Surveillance System.1980 - 1990年美国医院获得性真菌感染流行病学的长期趋势。国家医院感染监测系统。
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The yeast Candida albicans has a clonal mode of reproduction in a population of infected human immunodeficiency virus-positive patients.在一群感染了人类免疫缺陷病毒的阳性患者中，白色念珠菌以克隆繁殖方式存在。
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Mutation of human short tandem repeats.人类短串联重复序列的突变
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Identification of clinical strains of Candida albicans by DNA fingerprinting with the polymerase chain reaction.通过聚合酶链反应进行DNA指纹图谱分析鉴定白色念珠菌临床菌株。
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Genotypic characterization of sequential Candida albicans isolates from fluconazole-treated neutropenic patients.对氟康唑治疗的中性粒细胞减少患者中白色念珠菌连续分离株的基因分型特征分析
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Microsatellites and their application to population genetic studies.微卫星及其在群体遗传学研究中的应用。
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白色念珠菌延伸因子3基因启动子序列中的微卫星多态性作为一种分型系统的基础。

Microsatellite polymorphism in the promoter sequence of the elongation factor 3 gene of Candida albicans as the basis for a typing system.

作者信息

Bretagne S, Costa J M, Besmond C, Carsique R, Calderone R

机构信息

Laboratoire de Parasitologie-Mycologie, Hôpital Henri Mondor-Assistance Publique, Créteil, France.

出版信息

J Clin Microbiol. 1997 Jul;35(7):1777-80. doi: 10.1128/jcm.35.7.1777-1780.1997.

DOI:10.1128/jcm.35.7.1777-1780.1997
PMID:9196192
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC229840/
Abstract

The polymorphism of a TTC/TTTC microsatellite in the promoter sequence of the elongation factor 3 gene of Candida albicans was investigated by PCR. One primer was fluorescein labeled, and PCR signals were read with an automatic sequencer. Twenty-nine reference strains and 31 independent clinical isolates were studied. Eleven different alleles were identified, giving 16 different profiles among the 60 strains tested, with a discriminatory power of 0.88. This marker is stable upon subculture, and reproducibility was achieved by automated procedures. When several microsatellite markers are available, many isolates can be rapidly and reproducibly tested for epidemiological questions, such as the prevalence of a given strain in a hospital setting and transmission between patients.

摘要

采用聚合酶链反应（PCR）研究了白色念珠菌延伸因子3基因启动子序列中TTC/TTTC微卫星的多态性。其中一条引物用荧光素标记，PCR信号通过自动测序仪读取。研究了29株参考菌株和31株独立的临床分离株。鉴定出11种不同的等位基因，在60株测试菌株中产生了16种不同的图谱，鉴别力为0.88。该标记在传代培养时稳定，通过自动化程序可实现重复性。当有多个微卫星标记可用时，许多分离株可快速且可重复地用于流行病学问题的检测，例如医院环境中特定菌株的流行情况以及患者之间的传播。