针对HIV-1感染个体细胞成分的非器官特异性自身抗体。
Non-organ specific autoantibodies against cellular components in HIV-1 infected individuals.
作者信息
Kordossis T, Piha L, Guialis A, Kosmopoulou O, Tzioufas A G, Moutsopoulos H M
机构信息
Department of Pathophysiology, Medical School of Athens, Greece.
出版信息
Clin Exp Rheumatol. 1997 Mar-Apr;15(2):185-8.
OBJECTIVE
To detect the presence of autoantibodies against cellular components in HIV-1 infected individuals.
METHODS
Serum samples from 87 patients with HIV-1 infection and from 17 healthy HIV-seronegative controls were tested using sensitive and specific techniques (immunoblot, RNA precipitation), as well as counterimmunoelectrophoresis and indirect immunofluorescence.
RESULTS
Four sera (4.6%) showed reactivity in immunoblot against various unidentified cytoplasmic autoantigens. The four positive sera were obtained from patients belonging in equal numbers to the non-AIDS and AIDS groups.
CONCLUSION
It appears that the production of antibodies against cellular components rarely occurs during the clinical course of HIV infection.
目的
检测HIV-1感染个体中针对细胞成分的自身抗体的存在情况。
方法
采用灵敏且特异的技术（免疫印迹法、RNA沉淀法）以及对流免疫电泳和间接免疫荧光法，对87例HIV-1感染患者和17例HIV血清学阴性的健康对照者的血清样本进行检测。
结果
4份血清（4.6%）在免疫印迹中显示出针对各种未鉴定的细胞质自身抗原的反应性。这4份阳性血清分别来自非艾滋病组和艾滋病组，数量相等。
结论
在HIV感染的临床过程中，针对细胞成分的抗体产生似乎很少发生。
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