Pyy L, Mäkelä M, Hakala E, Kakko K, Lapinlampi T, Lisko A, Yrjänheikki E, Vähäkangas K
Oulu Regional Institute of Occupational Health, Finland.
Sci Total Environ. 1997 Jun 20;199(1-2):151-8. doi: 10.1016/s0048-9697(97)00065-x.
The exposure to polycyclic aromatic hydrocarbons (PAH) was measured in a Finnish coking plant over a 7-year period (1988-1994), since the beginning of production. Hygienic measurements including dust and vapour sampling were performed and the correlations between the concentrations of airborne pyrene with the levels of pyrene metabolite 1-pyrenol in urine were calculated. The profile of measured 12 or 15 PAHs was very similar between mean concentrations of personal samples, which suggests that it is possible to calculate the concentrations of total PAH by using e.g. pyrene as a marker compound. Measurements suggest that the progress of working conditions has been very favourable because the mean exposure level of shift workers to benzo[a]pyrene has decreased from 2.5 micrograms/m3 to 0.3 micrograms/m3. This points to successful measures of technical prevention. The mean concentration of 1-pyrenol in urine has been 0.2-0.6 mumol/mol creatinine. The concentration increases slightly towards the end of the working day, but the correlation urinary pyrenol and air pyrene was weak. Therefore the usefulness of pyrenol level for predicting the pyrene concentration at low exposure level in the ambient air is very limited.
自生产开始以来，在芬兰一家焦化厂对多环芳烃（PAH）暴露情况进行了为期7年（1988 - 1994年）的测量。进行了包括粉尘和蒸汽采样在内的卫生测量，并计算了空气中芘浓度与尿中芘代谢物1 - 芘醇水平之间的相关性。个人样本的平均浓度之间，所测的12种或15种多环芳烃的分布非常相似，这表明可以使用例如芘作为标记化合物来计算总多环芳烃的浓度。测量结果表明，工作条件的改善非常显著，因为轮班工人对苯并[a]芘的平均暴露水平已从2.5微克/立方米降至0.3微克/立方米。这表明技术预防措施取得了成功。尿中1 - 芘醇的平均浓度为0.2 - 0.6微摩尔/摩尔肌酐。在工作日结束时浓度略有上升，但尿中芘醇与空气中芘的相关性较弱。因此，在低暴露水平下，芘醇水平用于预测环境空气中芘浓度的作用非常有限。
