Brodie M J, Dichter M A
University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland, UK.
Seizure. 1997 Jun;6(3):159-74. doi: 10.1016/s1059-1311(97)80001-5.
Despite the recent entry into the market-place of a range of new pharmacological treatments for epilepsy, most patients still receive the standard antiepileptic drugs. This review considers the clinical place and practical use of these agents. Detailed consideration is given to carbamazepine, phenytoin, sodium valproate, phenobarbital and ethosuximide, with lesser emphasis on primidone, clobazam and clonazepam. Individualization of therapy, polypharmacy, refractory epilepsy, therapeutic drug monitoring, pregnancy, withdrawing treatment, epilepsy prophylaxis and referral to an epilepsy centre are also discussed. The paper concludes with a statement of 12 basic rules in prescribing established antiepileptic drugs.
尽管近期一系列用于癫痫的新药已进入市场，但大多数患者仍在使用标准抗癫痫药物。本综述探讨了这些药物的临床地位和实际应用。文中详细讨论了卡马西平、苯妥英、丙戊酸钠、苯巴比妥和乙琥胺，对扑米酮、氯巴占和氯硝西泮的讨论则相对较少。还讨论了治疗个体化、联合用药、难治性癫痫、治疗药物监测、妊娠、停药、癫痫预防以及转诊至癫痫中心等问题。本文最后列出了开具常用抗癫痫药物的12条基本规则。
