Doudna J A, Cate J H
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520-8114, USA.
Curr Opin Struct Biol. 1997 Jun;7(3):310-6. doi: 10.1016/s0959-440x(97)80045-0.
Structured RNAs play an essential role in chromosome maintenance, RNA processing, protein biosynthesis, and protein transport. To understand RNA function in these diverse biological systems, the rules for RNA folding and recognition must be learned. Recent crystal structures of hammerhead ribozymes, a group I intron domain, and RNA duplexes provide new insights into the principles of RNA folding and function.
结构化RNA在染色体维持、RNA加工、蛋白质生物合成及蛋白质运输中发挥着重要作用。为了解RNA在这些不同生物系统中的功能，必须掌握RNA折叠和识别的规则。锤头状核酶、I类内含子结构域及RNA双链体的最新晶体结构为RNA折叠和功能原理提供了新见解。
