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Quantitative determination of the glutathione, cysteine, and N-acetyl cysteine conjugates of acetaminophen by high-pressure liquid chromatography.

作者信息

Buckpitt A R, Rollins D E, Nelson S D, Franklin R B, Mitchell J R

出版信息

Anal Biochem. 1977 Nov;83(1):168-77. doi: 10.1016/0003-2697(77)90522-x.

DOI:10.1016/0003-2697(77)90522-x
PMID:920933
Abstract
摘要

相似文献

1
Quantitative determination of the glutathione, cysteine, and N-acetyl cysteine conjugates of acetaminophen by high-pressure liquid chromatography.
Anal Biochem. 1977 Nov;83(1):168-77. doi: 10.1016/0003-2697(77)90522-x.
2
Determination of glutathione, cysteine and N-acetylcysteine in rabbit eye tissues using high-performance liquid chromatography and post-column derivatization with 5,5'-dithiobis(2-nitrobenzoic acid).采用高效液相色谱法及5,5'-二硫代双(2-硝基苯甲酸)柱后衍生法测定兔眼组织中的谷胱甘肽、半胱氨酸和N-乙酰半胱氨酸。
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Determination of glutathione in biological material by high pressure liquid chromatography.用高压液相色谱法测定生物材料中的谷胱甘肽。
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5
Rapid detection and characterization of in vitro and urinary N-acetyl-L-cysteine conjugates using quadrupole-linear ion trap mass spectrometry and polarity switching.使用四极杆-线性离子阱质谱和极性切换技术对体外和尿液中的N-乙酰-L-半胱氨酸缀合物进行快速检测和表征。
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Simultaneous assessment of endogenous thiol compounds by LC-MS/MS.采用液相色谱-串联质谱法同时测定内源性硫醇化合物。
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7
Utility of solution electrochemistry mass spectrometry for investigating the formation and detection of biologically important conjugates of acetaminophen.
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8
Use of thermospray liquid chromatography-mass spectrometry for characterization of reactive metabolites of 3'-hydroxyacetanilide, a non-hepatotoxic regioisomer of acetaminophen.使用热喷雾液相色谱-质谱联用技术对3'-羟基乙酰苯胺（对乙酰氨基酚的一种非肝毒性区域异构体）的反应性代谢产物进行表征。
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Determination of intracellular glutathione and thiols by high performance liquid chromatography with a gold electrode at the femtomole level: comparison with a spectroscopic assay.采用带有金电极的高效液相色谱法在飞摩尔水平测定细胞内谷胱甘肽和硫醇：与光谱分析法的比较
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Determination of reduced, protein-unbound, and total concentrations of N-acetyl-L-cysteine and L-cysteine in rat plasma by postcolumn ligand substitution high-performance liquid chromatography.采用柱后配体置换高效液相色谱法测定大鼠血浆中还原型、非蛋白结合型及总N-乙酰-L-半胱氨酸和L-半胱氨酸的浓度。
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引用本文的文献

1
Mitogen-activated protein kinase phosphatase (Mkp)-1 protects mice against acetaminophen-induced hepatic injury.丝裂原活化蛋白激酶磷酸酶（Mkp）-1可保护小鼠免受对乙酰氨基酚诱导的肝损伤。
Toxicol Pathol. 2012 Dec;40(8):1095-105. doi: 10.1177/0192623312447551. Epub 2012 May 23.
2
Direct protection against acetaminophen hepatotoxicity by propylthiouracil. In vivo and in vitro studies in rats and mice.丙硫氧嘧啶对乙酰氨基酚肝毒性的直接保护作用。大鼠和小鼠的体内及体外研究。
J Clin Invest. 1981 Mar;67(3):688-95. doi: 10.1172/JCI110084.
3
Mechanism of action of N-acetylcysteine in the protection against the hepatotoxicity of acetaminophen in rats in vivo.
N-乙酰半胱氨酸对大鼠体内扑热息痛肝毒性保护作用的作用机制。
J Clin Invest. 1983 Apr;71(4):980-91. doi: 10.1172/jci110853.
4
Regulation of hepatic glutathione turnover in rats in vivo and evidence for kinetic homogeneity of the hepatic glutathione pool.大鼠体内肝脏谷胱甘肽周转的调节及肝脏谷胱甘肽池动力学均一性的证据。
J Clin Invest. 1981 May;67(5):1415-24. doi: 10.1172/jci110170.
5
Single dose oxazepam has no effect on acetaminophen clearance or metabolism.单次剂量的奥沙西泮对乙酰氨基酚的清除或代谢没有影响。
Eur J Clin Pharmacol. 1986;30(1):127-9. doi: 10.1007/BF00614210.