危地马拉一些传统上用于治疗疟疾的植物的体内和体外抗疟活性。
In vivo and in vitro antiplasmodial activities of some plants traditionally used in Guatemala against malaria.
作者信息
Franssen F F, Smeijsters L J, Berger I, Medinilla Aldana B E
机构信息
Department of Parasitology and Tropical Veterinary Medicine, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
出版信息
Antimicrob Agents Chemother. 1997 Jul;41(7):1500-3. doi: 10.1128/AAC.41.7.1500.
Abstract
We present an evaluation of the antiplasmodial and cytotoxic effects of four plants commonly used in Guatemalan folk medicine against malaria. Methanol extracts of Simarouba glauca D. C., Sansevieria guineensis Willd, Croton guatemalensis Lotsy, and Neurolaena lobata (L.)R.Br. significantly reduced parasitemias in Plasmodium berghei-infected mice. Dichloromethane fractions were screened for their cytotoxicities on Artemia salina (brine shrimp) larvae, and 50% inhibitory concentrations were determined for Plasmodium falciparum in in vitro cultures. Both chloroquine-susceptible and -resistant strains of P. falciparum were significantly inhibited by these extracts. Of all dichloromethane extracts, only the S. glauca cortex extract was considered to be toxic to nauplii of A. salina in the brine shrimp test.
摘要
我们对危地马拉民间医学中常用的四种植物抗疟原虫和细胞毒性作用进行了评估。绿心树（Simarouba glauca D. C.）、几内亚虎尾兰（Sansevieria guineensis Willd）、危地马拉巴豆（Croton guatemalensis Lotsy）和羽芒菊（Neurolaena lobata (L.)R.Br.）的甲醇提取物显著降低了感染伯氏疟原虫小鼠的疟原虫血症。对二氯甲烷馏分进行卤虫（盐水虾）幼虫细胞毒性筛选，并在体外培养中测定恶性疟原虫的50%抑制浓度。这些提取物对氯喹敏感和耐药的恶性疟原虫菌株均有显著抑制作用。在所有二氯甲烷提取物中，只有绿心树树皮提取物在盐水虾试验中被认为对卤虫无节幼体有毒。
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