一种来自圭亚那锡马树的新型抗疟苦木素类化合物。

A new antimalarial quassinoid from Simaba guianensis.

作者信息

Cabral J A, McChesney J D, Milhous W K

机构信息

Coordenação de Pesquisas em Produtos Naturais, Instituto Nacional de Pesquisas da Amazonia, Manaus, Brazil.

出版信息

J Nat Prod. 1993 Nov;56(11):1954-61. doi: 10.1021/np50101a014.

DOI:10.1021/np50101a014

PMID:8289064

Abstract

Two antimalarial quassinoids, gutolactone [1] and simalikalactone D [2], have been characterized by bioactivity-directed fractionation from the bark of Simaba guianensis collected near Manaus, Brazil. Compound 2 was previously isolated from Simaba multiflora and Quassia africana and shown to be an active antimalarial in vitro. This is the first occurrence of 1. The structure of the novel quassinoid was established by spectral methods including 2D nmr spectroscopy.

摘要

通过生物活性导向分级分离法，从采集于巴西玛瑙斯附近的圭亚那锡巴树树皮中鉴定出两种抗疟苦木素类化合物，即古托内酯[1]和西马卡内酯D[2]。化合物2先前已从多花锡巴树和非洲苦木中分离出来，并显示出体外抗疟活性。这是化合物1的首次发现。通过包括二维核磁共振光谱在内的光谱方法确定了这种新型苦木素类化合物的结构。