Leckman J F, Grice D E, Boardman J, Zhang H, Vitale A, Bondi C, Alsobrook J, Peterson B S, Cohen D J, Rasmussen S A, Goodman W K, McDougle C J, Pauls D L
Child Study Center, Yale University, School of Medicine, New Haven, CT 06520-7900, USA.
Am J Psychiatry. 1997 Jul;154(7):911-7. doi: 10.1176/ajp.154.7.911.
Obsessive-compulsive disorder encompasses a broad range of symptoms that represent multiple psychological domains, including perception, cognition, emotion, social relatedness, and diverse motor behaviors. The purpose of these analyses was to evaluate the correlational relationships of the symptoms of obsessive-compulsive disorder.
This study examined the 13 a priori categories used to group types of obsessions and compulsions in the Yale-Brown Obsessive Compulsive Scale symptom checklist in two independent groups of patients with obsessive-compulsive disorder (N = 208 and N = 98). A principal-components factor analysis with varimax rotation was performed, followed by a series of other exploratory analyses.
The two data sets yielded nearly identical results. Four factors--obsessions and checking, symmetry and ordering, cleanliness and washing, and boarding--emerged in each data set, in total accounting for more than 60% of the variance.
Obsessive-compulsive disorder is a multidimensional and etiologically heterogeneous condition. The four symptom dimensions identified in this study are largely congruent with those identified in earlier reports. These factors may be of value in future genetic, neurobiological, and treatment response studies.
强迫症包含一系列广泛的症状,这些症状代表了多个心理领域,包括感知、认知、情感、社会关系以及多样的运动行为。这些分析的目的是评估强迫症症状之间的相关关系。
本研究在两组独立的强迫症患者(N = 208和N = 98)中,检验了用于对耶鲁-布朗强迫症量表症状清单中的强迫观念和强迫行为类型进行分组的13个先验类别。进行了具有方差最大化旋转的主成分因子分析,随后进行了一系列其他探索性分析。
两个数据集得出了几乎相同的结果。每个数据集中都出现了四个因子——强迫观念与检查、对称与排序、清洁与洗涤以及囤积,总共占方差的60%以上。
强迫症是一种多维度且病因异质性的病症。本研究中确定的四个症状维度在很大程度上与早期报告中确定的维度一致。这些因子可能在未来的遗传、神经生物学和治疗反应研究中具有价值。